TY - JOUR
T1 - Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda
AU - Nabukalu, Dorean
AU - Reniers, Georges
AU - Risher, Kathryn A.
AU - Blom, Sylvia
AU - Slaymaker, Emma
AU - Kabudula, Chodziwadziwa
AU - Zaba, Basia
AU - Nalugoda, Fred
AU - Kigozi, Godfrey
AU - Makumbi, Fred
AU - Serwadda, David
AU - Reynolds, Steven J.
AU - Marston, Milly
AU - Eaton, Jeffrey W.
AU - Gray, Ron
AU - Wawer, Maria
AU - Sewankambo, Nelson
AU - Lutalo, Tom
N1 - Publisher Copyright:
© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/1/2
Y1 - 2020/1/2
N2 - There are limited data on the impact of antiretroviral therapy (ART) on population-level adult mortality in sub-Saharan Africa. We analysed data for 2000–14 from the Rakai Community Cohort Study (RCCS) in Uganda, where free ART was scaled up after 2004. Using non-parametric and parametric (Weibull) survival analysis, we estimated trends in average person-years lived between exact ages 15 and 50, per capita life-years lost to HIV, and the mortality hazards of people living with HIV (PLHIV). Between 2000 and 2014, average adult life-years lived before age 50 increased significantly, from 26.4 to 33.5 years for all women and from 28.6 to 33.8 years for all men. As of 2014, life-years lost to HIV had declined significantly, to 1.3 years among women and 0.4 years among men. Following the roll-out of ART, mortality reductions among PLHIV were initially larger in women than men, but this is no longer the case.
AB - There are limited data on the impact of antiretroviral therapy (ART) on population-level adult mortality in sub-Saharan Africa. We analysed data for 2000–14 from the Rakai Community Cohort Study (RCCS) in Uganda, where free ART was scaled up after 2004. Using non-parametric and parametric (Weibull) survival analysis, we estimated trends in average person-years lived between exact ages 15 and 50, per capita life-years lost to HIV, and the mortality hazards of people living with HIV (PLHIV). Between 2000 and 2014, average adult life-years lived before age 50 increased significantly, from 26.4 to 33.5 years for all women and from 28.6 to 33.8 years for all men. As of 2014, life-years lost to HIV had declined significantly, to 1.3 years among women and 0.4 years among men. Following the roll-out of ART, mortality reductions among PLHIV were initially larger in women than men, but this is no longer the case.
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U2 - 10.1080/00324728.2019.1595099
DO - 10.1080/00324728.2019.1595099
M3 - Article
C2 - 31117928
AN - SCOPUS:85066875597
SN - 0032-4728
VL - 74
SP - 93
EP - 102
JO - Population Studies
JF - Population Studies
IS - 1
ER -