Population-level antibody estimates to novel influenza A/H7N9

Maciej F. Boni; Nguyen Van Vinh Chau; Nguyen Dong; Stacy Todd; Nguyen Thi Duy Nhat; Erwin De Bruin; Janko Van Beek; Nguyen Tran Hien; Cameron P. Simmons; Jeremy Farrar; Marion Koopmans

doi:10.1093/infdis/jit224

Population-level antibody estimates to novel influenza A/H7N9

Maciej F. Boni, Nguyen Van Vinh Chau, Nguyen Dong, Stacy Todd, Nguyen Thi Duy Nhat, Erwin De Bruin, Janko Van Beek, Nguyen Tran Hien, Cameron P. Simmons, Jeremy Farrar, Marion Koopmans

Biology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

Original language	English (US)
Pages (from-to)	554-558
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	208
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jit224
State	Published - Aug 15 2013

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jit224

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title = "Population-level antibody estimates to novel influenza A/H7N9",

abstract = "There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.",

author = "Boni, {Maciej F.} and {Van Vinh Chau}, Nguyen and Nguyen Dong and Stacy Todd and Nhat, {Nguyen Thi Duy} and {De Bruin}, Erwin and {Van Beek}, Janko and Hien, {Nguyen Tran} and Simmons, {Cameron P.} and Jeremy Farrar and Marion Koopmans",

note = "Funding Information: Financial support. This work was supported by the Wellcome Trust (098511/Z/12/Z, 089276/B/09/7, 097465/B/11/Z, 084368/Z/07/Z), the British Medical Association (HC Roscoe 2011), and the Dutch Ministry of Economic Affairs, Agriculture, and Innovation, Castellum Project. Potential conflict of interest. All authors: No reported conflicts.",

year = "2013",

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doi = "10.1093/infdis/jit224",

language = "English (US)",

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pages = "554--558",

journal = "Journal of Infectious Diseases",

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AU - Boni, Maciej F.

AU - Van Vinh Chau, Nguyen

AU - Dong, Nguyen

AU - Todd, Stacy

AU - Nhat, Nguyen Thi Duy

AU - De Bruin, Erwin

AU - Van Beek, Janko

AU - Hien, Nguyen Tran

AU - Simmons, Cameron P.

AU - Farrar, Jeremy

AU - Koopmans, Marion

N1 - Funding Information: Financial support. This work was supported by the Wellcome Trust (098511/Z/12/Z, 089276/B/09/7, 097465/B/11/Z, 084368/Z/07/Z), the British Medical Association (HC Roscoe 2011), and the Dutch Ministry of Economic Affairs, Agriculture, and Innovation, Castellum Project. Potential conflict of interest. All authors: No reported conflicts.

PY - 2013/8/15

Y1 - 2013/8/15

N2 - There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

AB - There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

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Population-level antibody estimates to novel influenza A/H7N9

Abstract

All Science Journal Classification (ASJC) codes

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