Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas

Gihoon Choi; Theodore J. Prince; Jun Miao; Liwang Cui; Weihua Guan

Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas

Gihoon Choi
, Theodore J. Prince
, Jun Miao
, Liwang Cui
, Weihua Guan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper reports a multiplexed “sample-in-answer-out” diagnostic system for species-specific molecular detection of malaria (P. falciparum and P. vivax) in field settings. The multiplexed system aims to address the need for sensitive and species-specific detection of malaria in field clinics. The multiplexed diagnostic system incorporates a ready-to-use reagent compact disk (with multiple independent species-specific reaction units) and a portable analyzer. Using whole blood as a testing sample, the multiplexed system can deliver fast (40 mins from raw sample to answer), sensitive (~1.6 parasites/μL), and specific (P. falciparum and P. vivax) molecular answers without laboratory infrastructures.

Original language	English (US)
Title of host publication	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Publisher	Chemical and Biological Microsystems Society
Pages	1179-1180
Number of pages	2
ISBN (Electronic)	9780692941836
State	Published - Jan 1 2020
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: Oct 22 2017 → Oct 26 2017

Publication series

Name	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/Territory	United States
City	Savannah
Period	10/22/17 → 10/26/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

Choi, G., Prince, T. J., Miao, J., Cui, L., & Guan, W. (2020). Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1179-1180). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.

Choi, Gihoon ; Prince, Theodore J. ; Miao, Jun et al. / Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas. 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, 2020. pp. 1179-1180 (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

@inproceedings{b21a01aeeefd40f09dc61875f4636f79,

title = "Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas",

abstract = "This paper reports a multiplexed “sample-in-answer-out” diagnostic system for species-specific molecular detection of malaria (P. falciparum and P. vivax) in field settings. The multiplexed system aims to address the need for sensitive and species-specific detection of malaria in field clinics. The multiplexed diagnostic system incorporates a ready-to-use reagent compact disk (with multiple independent species-specific reaction units) and a portable analyzer. Using whole blood as a testing sample, the multiplexed system can deliver fast (40 mins from raw sample to answer), sensitive (\textasciitilde{}1.6 parasites/μL), and specific (P. falciparum and P. vivax) molecular answers without laboratory infrastructures.",

author = "Gihoon Choi and Prince, \{Theodore J.\} and Jun Miao and Liwang Cui and Weihua Guan",

year = "2020",

month = jan,

day = "1",

language = "English (US)",

series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",

publisher = "Chemical and Biological Microsystems Society",

pages = "1179--1180",

booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",

note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",

}

Choi, G, Prince, TJ, Miao, J, Cui, L & Guan, W 2020, Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas. in 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, Chemical and Biological Microsystems Society, pp. 1179-1180, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, Savannah, United States, 10/22/17.

Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas. / Choi, Gihoon; Prince, Theodore J.; Miao, Jun et al.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, 2020. p. 1179-1180 (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas

AU - Choi, Gihoon

AU - Prince, Theodore J.

AU - Miao, Jun

AU - Cui, Liwang

AU - Guan, Weihua

PY - 2020/1/1

Y1 - 2020/1/1

N2 - This paper reports a multiplexed “sample-in-answer-out” diagnostic system for species-specific molecular detection of malaria (P. falciparum and P. vivax) in field settings. The multiplexed system aims to address the need for sensitive and species-specific detection of malaria in field clinics. The multiplexed diagnostic system incorporates a ready-to-use reagent compact disk (with multiple independent species-specific reaction units) and a portable analyzer. Using whole blood as a testing sample, the multiplexed system can deliver fast (40 mins from raw sample to answer), sensitive (~1.6 parasites/μL), and specific (P. falciparum and P. vivax) molecular answers without laboratory infrastructures.

AB - This paper reports a multiplexed “sample-in-answer-out” diagnostic system for species-specific molecular detection of malaria (P. falciparum and P. vivax) in field settings. The multiplexed system aims to address the need for sensitive and species-specific detection of malaria in field clinics. The multiplexed diagnostic system incorporates a ready-to-use reagent compact disk (with multiple independent species-specific reaction units) and a portable analyzer. Using whole blood as a testing sample, the multiplexed system can deliver fast (40 mins from raw sample to answer), sensitive (~1.6 parasites/μL), and specific (P. falciparum and P. vivax) molecular answers without laboratory infrastructures.

UR - https://www.scopus.com/pages/publications/85079622614

UR - https://www.scopus.com/pages/publications/85079622614#tab=citedBy

M3 - Conference contribution

T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

SP - 1179

EP - 1180

BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

PB - Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Y2 - 22 October 2017 through 26 October 2017

ER -

Choi G, Prince TJ, Miao J, Cui L, Guan W. Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society. 2020. p. 1179-1180. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas

Abstract

Publication series

Conference

UN SDGs

All Science Journal Classification (ASJC) codes

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Cite this