Abstract
Interactions between the cAMP receptor protein (CRP) and the carboxy- terminal regulatory domain (CTD) of Escherichia coli RNA polymerase α subunit were analyzed at promoters carrying tandem DNA sites for CRP binding using a chemical nuclease covalently attached to α each CRP dimer was found to direct the positioning of one of the two α subunit CTDs. Thus, the function of RNA polymerase may be subject to regulation through protein- protein interactions between the two α subunits and two different species of transcription factors.
Original language | English (US) |
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Pages (from-to) | 11274-11278 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 94 |
Issue number | 21 |
DOIs | |
State | Published - Oct 14 1997 |
All Science Journal Classification (ASJC) codes
- General