Positive genetic feedback governs cAMP spiral wave formation in Dictyostelium

Herbert Levine, Igor Aranson, Lev Tsimring, Thai Viet Truong

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


The aggregation stage of the life cycle of Dictyostelium discoideum is governed by the chemotactic response of individual amoebae to excitable waves of cAMP. We modeled this process through a recently introduced hybrid automata-continuum scheme and used computer simulation to unravel the role of specific components of this complex developmental process. Our results indicated an essential role for positive feedback between the cAMP signaling and the expression of the genes encoding the signal transduction and response machinery.

Original languageEnglish (US)
Pages (from-to)6382-6386
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number13
StatePublished - Jun 25 1996

All Science Journal Classification (ASJC) codes

  • General


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