Positive panel reactive antibody titers in patients bridged to transplantation with a mechanical assist device: Risk factors and treatment

Pei H. Tsau; Francisco A. Arabía; Bruce Toporoff; Venki Paramesh; Gulshan K. Sethi; Jack G. Copeland

doi:10.1097/00002480-199809000-00067

Positive panel reactive antibody titers in patients bridged to transplantation with a mechanical assist device: Risk factors and treatment

Pei H. Tsau, Francisco A. Arabía, Bruce Toporoff, Venki Paramesh, Gulshan K. Sethi, Jack G. Copeland

Department of Surgery

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Patients who are bridged-to-transplantation with mechanical support have a high incidence of pretransplant sensitization defined by panel reactive antibody (PRA) titers greater than 10. Risk factors for positive PRA in patients with assist devices were investigated. It is recommended that patients who are bridged-to-transplantation with assist devices and have high PRA levels be treated with perioperative plasmapheresis. With this aggressive approach, it may no longer be necessary to keep patients on mechanical support for prolonged periods, but possible to perform transplants as soon as suitable donors become available.

Original language	English (US)
Pages (from-to)	M634-M637
Journal	ASAIO Journal
Volume	44
Issue number	5
DOIs	https://doi.org/10.1097/00002480-199809000-00067
State	Published - 1998

All Science Journal Classification (ASJC) codes

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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abstract = "Patients who are bridged-to-transplantation with mechanical support have a high incidence of pretransplant sensitization defined by panel reactive antibody (PRA) titers greater than 10. Risk factors for positive PRA in patients with assist devices were investigated. It is recommended that patients who are bridged-to-transplantation with assist devices and have high PRA levels be treated with perioperative plasmapheresis. With this aggressive approach, it may no longer be necessary to keep patients on mechanical support for prolonged periods, but possible to perform transplants as soon as suitable donors become available.",

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AU - Paramesh, Venki

AU - Sethi, Gulshan K.

AU - Copeland, Jack G.

PY - 1998

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AB - Patients who are bridged-to-transplantation with mechanical support have a high incidence of pretransplant sensitization defined by panel reactive antibody (PRA) titers greater than 10. Risk factors for positive PRA in patients with assist devices were investigated. It is recommended that patients who are bridged-to-transplantation with assist devices and have high PRA levels be treated with perioperative plasmapheresis. With this aggressive approach, it may no longer be necessary to keep patients on mechanical support for prolonged periods, but possible to perform transplants as soon as suitable donors become available.

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Positive panel reactive antibody titers in patients bridged to transplantation with a mechanical assist device: Risk factors and treatment

Abstract

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