TY - JOUR
T1 - Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer
AU - REACCT COLLABORATIVE
AU - O’Connell, Lauren V.
AU - Zaborowski, Alexandra M.
AU - Abdile, Ahmed
AU - Adamina, Michel
AU - Aigner, Felix
AU - D’Allens, Laura
AU - Allmer, Caterina
AU - Álvarez, Andrea
AU - Anula, Rocio
AU - Andric, Mihailo
AU - Bach, Sam Atallah Simon
AU - Bala, Miklosh
AU - Barussaud, Marie
AU - Bausys, Augustinas
AU - Beggs, Andrew
AU - Bellolio, Felipe
AU - Bennett, Melissa Rose
AU - Bevan, Vicki
AU - Biondo, Sebastiano
AU - Bislenghi, Gabriele
AU - Bludau, Marc
AU - Brown, Carl
AU - Bruns, Christiane
AU - Buchanan, Daniel D.
AU - Buchwald, Pamela
AU - Burger, Jacobus W.A.
AU - Burlov, Nikita
AU - Campanelli, Michela
AU - Capdepont, Maylis
AU - Carvello, Michele
AU - Chew, Hwee Hoon
AU - Christoforidis, Dimitri
AU - Clark, David
AU - Climent, Marta
AU - Collinson, Rowan
AU - Cologne, Kyle G.
AU - Contreras, Tomas
AU - Croner, Roland
AU - Daniels, Ian R.
AU - Dapri, Giovanni
AU - Davies, Justin
AU - Delrio, Paolo
AU - Denost, Quentin
AU - Deutsch, Michael
AU - Dias, Andre
AU - D’Hoore, André
AU - Drozdov, Evgeniy
AU - Duek, Daniel
AU - Dunlop, Malcolm
AU - Dziki, Adam
N1 - Publisher Copyright:
Copyright © 2022 REACCT Collaborative.
PY - 2022/5/30
Y1 - 2022/5/30
N2 - Background: Impairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (<50 years) is rising, there is little data on functional outcomes in this group. Methods: The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, <50 years of age at time of diagnosis and with documented follow-up including functional outcomes. Results: A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%). Conclusion: A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters.
AB - Background: Impairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (<50 years) is rising, there is little data on functional outcomes in this group. Methods: The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, <50 years of age at time of diagnosis and with documented follow-up including functional outcomes. Results: A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%). Conclusion: A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters.
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U2 - 10.3389/fonc.2022.868359
DO - 10.3389/fonc.2022.868359
M3 - Article
C2 - 35707361
AN - SCOPUS:85133934774
SN - 2234-943X
VL - 12
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 868359
ER -