TY - JOUR
T1 - Post-transcriptional regulation of immunological responses through riboclustering
AU - Ganguly, Koelina
AU - Giddaluru, Jeevan
AU - August, Avery
AU - Khan, Nooruddin
N1 - Publisher Copyright:
© 2016 Ganguly, Giddaluru, August and Khan.
PY - 2016/4/29
Y1 - 2016/4/29
N2 - Immunological programing of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation, tolerance, and plasticity of the immune system. RNA-binding proteins (RBPs) recruited by the specific sequence elements in mRNA transcripts are one such modifiers. These RBPs form RBP-RNA complexes known as "riboclusters." These riboclusters serve as RNA sorting machinery, where depending upon the composition of the ribocluster, translation, degradation, or storage of mRNA is controlled. Recent findings suggest that this regulation of mRNA homeostasis is critical for controlling the immune response. Here, we present the current knowledge of the ribocluster-mediated post-transcriptional regulation of immune mediators and highlight recent findings regarding their implications for the pathogenesis of acute or chronic inflammatory diseases.
AB - Immunological programing of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation, tolerance, and plasticity of the immune system. RNA-binding proteins (RBPs) recruited by the specific sequence elements in mRNA transcripts are one such modifiers. These RBPs form RBP-RNA complexes known as "riboclusters." These riboclusters serve as RNA sorting machinery, where depending upon the composition of the ribocluster, translation, degradation, or storage of mRNA is controlled. Recent findings suggest that this regulation of mRNA homeostasis is critical for controlling the immune response. Here, we present the current knowledge of the ribocluster-mediated post-transcriptional regulation of immune mediators and highlight recent findings regarding their implications for the pathogenesis of acute or chronic inflammatory diseases.
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U2 - 10.3389/fimmu.2016.00161
DO - 10.3389/fimmu.2016.00161
M3 - Review article
C2 - 27199986
AN - SCOPUS:84966708512
SN - 1664-3224
VL - 7
JO - Frontiers in immunology
JF - Frontiers in immunology
IS - APR
M1 - 161
ER -