Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism

Jana W. Qiao; Yongwook Dan; Michael E. Wolf; Christina M. Zoccoli; Theodore J. Demetriou; Robert P. Lennon

doi:10.1093/milmed/usab314

Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism

Jana W. Qiao, Yongwook Dan, Michael E. Wolf, Christina M. Zoccoli, Theodore J. Demetriou, Robert P. Lennon

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Coronavirus disease (COVID) toes are pernio-like skin lesions associated with severe acute respiratory syndrome coronavirus 2. We observed pernio-like skin findings presenting after a Pfizer BioNTech vaccine, which significantly worsened after an infusion of rituximab. This suggests that the mechanism for COVID toes is interferon activation. Military providers may avoid unnecessary referrals for this self-limiting condition by anticipating this adverse effect.

Original language	English (US)
Pages (from-to)	E1563-E1565
Journal	Military medicine
Volume	187
Issue number	11-12
DOIs	https://doi.org/10.1093/milmed/usab314
State	Published - Nov 1 2022

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General Medicine

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10.1093/milmed/usab314

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title = "Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism",

abstract = "Coronavirus disease (COVID) toes are pernio-like skin lesions associated with severe acute respiratory syndrome coronavirus 2. We observed pernio-like skin findings presenting after a Pfizer BioNTech vaccine, which significantly worsened after an infusion of rituximab. This suggests that the mechanism for COVID toes is interferon activation. Military providers may avoid unnecessary referrals for this self-limiting condition by anticipating this adverse effect.",

author = "Qiao, \{Jana W.\} and Yongwook Dan and Wolf, \{Michael E.\} and Zoccoli, \{Christina M.\} and Demetriou, \{Theodore J.\} and Lennon, \{Robert P.\}",

note = "Publisher Copyright: {\textcopyright} The Association of Military Surgeons of the United States 2021.",

year = "2022",

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doi = "10.1093/milmed/usab314",

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T1 - Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism

AU - Qiao, Jana W.

AU - Dan, Yongwook

AU - Wolf, Michael E.

AU - Zoccoli, Christina M.

AU - Demetriou, Theodore J.

AU - Lennon, Robert P.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Coronavirus disease (COVID) toes are pernio-like skin lesions associated with severe acute respiratory syndrome coronavirus 2. We observed pernio-like skin findings presenting after a Pfizer BioNTech vaccine, which significantly worsened after an infusion of rituximab. This suggests that the mechanism for COVID toes is interferon activation. Military providers may avoid unnecessary referrals for this self-limiting condition by anticipating this adverse effect.

AB - Coronavirus disease (COVID) toes are pernio-like skin lesions associated with severe acute respiratory syndrome coronavirus 2. We observed pernio-like skin findings presenting after a Pfizer BioNTech vaccine, which significantly worsened after an infusion of rituximab. This suggests that the mechanism for COVID toes is interferon activation. Military providers may avoid unnecessary referrals for this self-limiting condition by anticipating this adverse effect.

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JO - Military medicine

JF - Military medicine

IS - 11-12

ER -

Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism

Abstract

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