TY - JOUR
T1 - Postprandial effects on arterial stiffness parameters in healthy young adults
AU - Murray, Tyler
AU - Yang, Eric Y.
AU - Brunner, Gerd
AU - Kumar, Anirudh
AU - Lakkis, Nasser
AU - Misra, Arunima
AU - Virani, Salim S.
AU - Hartley, Craig J.
AU - Morrisett, Joel D.
AU - Ballantyne, Christie M.
AU - Nambi, Vijay
N1 - Publisher Copyright:
© SAGE Publications.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Postprandial lipemia has been associated with acute endothelial dysfunction. Endothelial dysfunction, in turn, is associated with increased arterial stiffness. However, the relationship between postprandial lipemia and acute changes in arterial stiffness has not been extensively investigated. Therefore, we conducted a pilot study on the effects of postprandial lipemia on arterial stiffness in 19 healthy young adults before and after consumption of a high-fat mixed meal. Arterial stiffness was assessed locally with echo-tracking carotid arterial strain (CAS) and globally with carotid-femoral pulse wave velocity (PWV). As assessed by these two benchmark parameters, arterial stiffness did not differ significantly postprandially. However, the arterial distension period (ADP) was significantly lower 2 hours after mixed meal ingestion. In addition, slopes of carotid artery area (CAA) curves were significantly steeper postprandially. Therefore, we concluded that ADP may be a more sensitive marker of arterial stiffness in healthy young adults when compared to PWV and CAS.
AB - Postprandial lipemia has been associated with acute endothelial dysfunction. Endothelial dysfunction, in turn, is associated with increased arterial stiffness. However, the relationship between postprandial lipemia and acute changes in arterial stiffness has not been extensively investigated. Therefore, we conducted a pilot study on the effects of postprandial lipemia on arterial stiffness in 19 healthy young adults before and after consumption of a high-fat mixed meal. Arterial stiffness was assessed locally with echo-tracking carotid arterial strain (CAS) and globally with carotid-femoral pulse wave velocity (PWV). As assessed by these two benchmark parameters, arterial stiffness did not differ significantly postprandially. However, the arterial distension period (ADP) was significantly lower 2 hours after mixed meal ingestion. In addition, slopes of carotid artery area (CAA) curves were significantly steeper postprandially. Therefore, we concluded that ADP may be a more sensitive marker of arterial stiffness in healthy young adults when compared to PWV and CAS.
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U2 - 10.1177/1358863X15587044
DO - 10.1177/1358863X15587044
M3 - Article
C2 - 26060082
AN - SCOPUS:84947902261
SN - 1358-863X
VL - 20
SP - 501
EP - 508
JO - Vascular Medicine (United Kingdom)
JF - Vascular Medicine (United Kingdom)
IS - 6
ER -