TY - JOUR
T1 - Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins
AU - Babitzke, Paul
AU - Lai, Ying Jung
AU - Renda, Andrew J.
AU - Romeo, Tony
N1 - Publisher Copyright:
© 2019 by Annual Reviews. All rights reserved.
PY - 2019
Y1 - 2019
N2 - RNA-binding proteins play vital roles in regulating gene expression and cellular physiology in all organisms. Bacterial RNA-binding proteins can regulate transcription termination via attenuation or antitermination mechanisms, while others can repress or activate translation initiation by affecting ribosome binding. The RNA targets for these proteins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features. The activity of these proteins can be influenced by binding of metabolites, small RNAs, or other proteins, as well as by phosphorylation events. Some of these proteins regulate specific genes, while others function as global regulators. As the regulatory mechanisms, components, targets, and signaling circuitry surrounding RNA-binding proteins have become better understood, in part through rapid advances provided by systems approaches, a sense of the true nature of biological complexity is becoming apparent, which we attempt to capture for the reader of this review.
AB - RNA-binding proteins play vital roles in regulating gene expression and cellular physiology in all organisms. Bacterial RNA-binding proteins can regulate transcription termination via attenuation or antitermination mechanisms, while others can repress or activate translation initiation by affecting ribosome binding. The RNA targets for these proteins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features. The activity of these proteins can be influenced by binding of metabolites, small RNAs, or other proteins, as well as by phosphorylation events. Some of these proteins regulate specific genes, while others function as global regulators. As the regulatory mechanisms, components, targets, and signaling circuitry surrounding RNA-binding proteins have become better understood, in part through rapid advances provided by systems approaches, a sense of the true nature of biological complexity is becoming apparent, which we attempt to capture for the reader of this review.
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U2 - 10.1146/annurev-micro-020518-115907
DO - 10.1146/annurev-micro-020518-115907
M3 - Review article
C2 - 31100987
AN - SCOPUS:85072057535
SN - 0066-4227
VL - 73
SP - 43
EP - 67
JO - Annual Review of Microbiology
JF - Annual Review of Microbiology
ER -