Potassium-channel opener cardioplegia is superior to St. Thomas' solution in the intact animal

A. Mark Jayawant, Edward R. Stephenson, Gregory S. Matte, George A. Prophet, Kathryn F. Lanoue, James W. Griffith, Ralph J. Damiano

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background. In isolated hearts, the potassium-channel opener pinacidil is an effective cardioplegic agent. This study tested the hypothesis that pinacidil is superior to St. Thomas' solution in the more clinically relevant intact animal.Methods. Sixteen pigs were placed on full cardiopulmonary bypass. Hearts underwent 2 hours of global ischemia (10°to 15°C). Either St. Thomas' or 100 μmol/L pinacidil was administered every 20 minutes (10 mL/kg). Preischemic and postreperfusion slopes of the preload-recruitable stroke work relationship were determined. Changes in myocardial adenine nucleotide levels and cellular ultrastructure were analyzed.Results. Pinacidil cardioplegia resulted in an insignificant change in the slope of the preload-recruitable stroke work relationship (40.6 ± 2.1 mm Hg/mm before ischemia and 36.5 ± 3.7 mm Hg/mm after ischemia; p = 0.466). In contrast, St. Thomas' solution resulted in a significant decrease in the slope after reperfusion (34.3 ± 5.5 mm Hg/mm and 13.5 ± 2.3 mm Hg/mm; p = 0.003). Adenine nucleotide levels, myocardial tissue water, and ultrastructural changes were similar between groups.Conclusions. Pinacidil ameliorated myocardial stunning associated with traditional hyperkalemic cardioplegia without causing significant differences in cellular metabolism. Copyright (C) 1999 The Society of Thoracic Surgeons.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number1
StatePublished - Jul 1999

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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