Potent inhibitors of the MAP kinase p38

James R. Henry; Kenneth C. Rupert; John H. Dodd; Ignatius J. Turchi; Scott A. Wadsworth; Druie E. Cavender; Peter H. Schafer; John J. Siekierka

doi:10.1016/S0960-894X(98)00589-7

Potent inhibitors of the MAP kinase p38

James R. Henry, Kenneth C. Rupert, John H. Dodd, Ignatius J. Turchi, Scott A. Wadsworth, Druie E. Cavender, Peter H. Schafer, John J. Siekierka

Chemistry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

Original language	English (US)
Pages (from-to)	3335-3340
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(98)00589-7
State	Published - Dec 1 1998

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(98)00589-7

Cite this

@article{a87eaf958f9949208f3e09b25e9a9a7b,

title = "Potent inhibitors of the MAP kinase p38",

abstract = "The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.",

author = "Henry, {James R.} and Rupert, {Kenneth C.} and Dodd, {John H.} and Turchi, {Ignatius J.} and Wadsworth, {Scott A.} and Cavender, {Druie E.} and Schafer, {Peter H.} and Siekierka, {John J.}",

year = "1998",

month = dec,

day = "1",

doi = "10.1016/S0960-894X(98)00589-7",

language = "English (US)",

volume = "8",

pages = "3335--3340",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "23",

}

TY - JOUR

T1 - Potent inhibitors of the MAP kinase p38

AU - Henry, James R.

AU - Rupert, Kenneth C.

AU - Dodd, John H.

AU - Turchi, Ignatius J.

AU - Wadsworth, Scott A.

AU - Cavender, Druie E.

AU - Schafer, Peter H.

AU - Siekierka, John J.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

AB - The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

UR - http://www.scopus.com/inward/record.url?scp=0032401112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032401112&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(98)00589-7

DO - 10.1016/S0960-894X(98)00589-7

M3 - Article

C2 - 9873730

AN - SCOPUS:0032401112

SN - 0960-894X

VL - 8

SP - 3335

EP - 3340

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Potent inhibitors of the MAP kinase p38

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this