TY - JOUR
T1 - Potential influence of total parenteral nutrition on body composition at discharge in preterm infants
AU - Meyers, Jeffrey M.
AU - Greecher, Coleen P.
AU - Shaffer, Michele L.
AU - Shenberger, Jeffrey S.
PY - 2013/10
Y1 - 2013/10
N2 - Objective: This study was undertaken to assess the potential influence of total parenteral nutrition (TPN) on body composition (BC) in preterm infants. Study design: This prospective, observational study of infants born <35 weeks measured BC at discharge using air displacement plethysmography. The % body fat (BF) at discharge was correlated with variables gestational age (GA), severity of illness, days on oxygen, time to regain birth weight and duration of TPN. Result: The 61 patients enrolled had a %BF at discharge of 13.9%. GA and TPN days correlated with %BF for the entire group. Multiple regression analysis identified that the time to regain birth weight added to the effect of GA, but not TPN. Isolating the influence of TPN in a subgroup of similarly aged infants (30-35 weeks) did not reveal a difference in body composition at the time of discharge between infants who did or did not receive TPN. Conclusion: These findings fail to demonstrate a clear influence of TPN on the increased accrual of BF in premature infants and implicate gestational modification in nutrient/caloric utilization as a principle regulator of body composition in premature newborns.
AB - Objective: This study was undertaken to assess the potential influence of total parenteral nutrition (TPN) on body composition (BC) in preterm infants. Study design: This prospective, observational study of infants born <35 weeks measured BC at discharge using air displacement plethysmography. The % body fat (BF) at discharge was correlated with variables gestational age (GA), severity of illness, days on oxygen, time to regain birth weight and duration of TPN. Result: The 61 patients enrolled had a %BF at discharge of 13.9%. GA and TPN days correlated with %BF for the entire group. Multiple regression analysis identified that the time to regain birth weight added to the effect of GA, but not TPN. Isolating the influence of TPN in a subgroup of similarly aged infants (30-35 weeks) did not reveal a difference in body composition at the time of discharge between infants who did or did not receive TPN. Conclusion: These findings fail to demonstrate a clear influence of TPN on the increased accrual of BF in premature infants and implicate gestational modification in nutrient/caloric utilization as a principle regulator of body composition in premature newborns.
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U2 - 10.3109/14767058.2013.793663
DO - 10.3109/14767058.2013.793663
M3 - Article
C2 - 23578184
AN - SCOPUS:84884563473
SN - 1476-7058
VL - 26
SP - 1548
EP - 1553
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 15
ER -