Potential new therapies for perinatal cerebral hypoxia-ischemia

Charles Palmer, R. C. Vannucci

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Recent studies in neonatal animals have shown that hypoxic-ischemic brain damage can be reduced by interventions initiated after the hypoxic-ischemic insult. In this article, the authors focus on potentially new modalities of therapy capable of preventing - or at least reducing - brain damage arising from perinatal cerebral hypoxia-ischemia. Management strategies include oxygen-free radical inhibitors and scavengers, excitatory amino acid antagonists, and calcium channel blocker. Additional information is provided regarding the critical role of glucose in perinatal cerebral hypoxia-ischemia and also the protective effect of hypothermia on preventing brain damage.

Original languageEnglish (US)
Pages (from-to)411-432
Number of pages22
JournalClinics in Perinatology
Issue number2
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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