Abstract
Recent studies in neonatal animals have shown that hypoxic-ischemic brain damage can be reduced by interventions initiated after the hypoxic-ischemic insult. In this article, the authors focus on potentially new modalities of therapy capable of preventing - or at least reducing - brain damage arising from perinatal cerebral hypoxia-ischemia. Management strategies include oxygen-free radical inhibitors and scavengers, excitatory amino acid antagonists, and calcium channel blocker. Additional information is provided regarding the critical role of glucose in perinatal cerebral hypoxia-ischemia and also the protective effect of hypothermia on preventing brain damage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 411-432 |
| Number of pages | 22 |
| Journal | Clinics in Perinatology |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1993 |
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology