TY - GEN
T1 - Potential role of UGT pharmacogenetics in cancer treatment and prevention
T2 - Focus on tamoxifen
AU - Lazarus, Philip
AU - Blevins-Primeau, Andrea S.
AU - Zheng, Yan
AU - Sun, Dongxiao
PY - 2009/2
Y1 - 2009/2
N2 - Tamoxifen (TAM) is a selective estrogen receptor modulator that is widely used in the prevention and treatment of estrogen receptor-positive (ER +) breast cancer. Its use has significantly contributed to a decline in breast cancer mortality, since breast cancer patients treated with TAM for 5 years exhibit a 30-50% reduction in both the rate of disease recurrence after 10 years of patient follow-up and occurrence of contralateral breast cancer. However, in patients treated with TAM there is substantial interindividual variability in the development of resistance to TAM therapy, and in the incidence of TAM-induced adverse events, including deep vein thrombosis, hot flashes, and the development of endometrial cancer. This article will focus on the UDP glucuronosyltransferases, a family of metabolizing enzymes that are responsible for the deactivation and clearance of TAM and TAM metabolites, and how interindividual differences in these enzymes may play a role in patient response to TAM.
AB - Tamoxifen (TAM) is a selective estrogen receptor modulator that is widely used in the prevention and treatment of estrogen receptor-positive (ER +) breast cancer. Its use has significantly contributed to a decline in breast cancer mortality, since breast cancer patients treated with TAM for 5 years exhibit a 30-50% reduction in both the rate of disease recurrence after 10 years of patient follow-up and occurrence of contralateral breast cancer. However, in patients treated with TAM there is substantial interindividual variability in the development of resistance to TAM therapy, and in the incidence of TAM-induced adverse events, including deep vein thrombosis, hot flashes, and the development of endometrial cancer. This article will focus on the UDP glucuronosyltransferases, a family of metabolizing enzymes that are responsible for the deactivation and clearance of TAM and TAM metabolites, and how interindividual differences in these enzymes may play a role in patient response to TAM.
UR - http://www.scopus.com/inward/record.url?scp=61649101234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61649101234&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04114.x
DO - 10.1111/j.1749-6632.2009.04114.x
M3 - Conference contribution
C2 - 19250197
AN - SCOPUS:61649101234
SN - 9781573317450
T3 - Annals of the New York Academy of Sciences
SP - 99
EP - 111
BT - Steroid Enzymes and Cancer
PB - Blackwell Publishing Inc.
ER -
