Potential roles of adropin in central nervous system: Review of current literature

Shima Shahjouei, Saeed Ansari, Tayebeh Pourmotabbed, Ramin Zand

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.

Original languageEnglish (US)
Article number25
JournalFrontiers in Molecular Biosciences
Volume3
Issue numberJUN
DOIs
StatePublished - Jun 27 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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