TY - JOUR
T1 - Potential roles of adropin in central nervous system
T2 - Review of current literature
AU - Shahjouei, Shima
AU - Ansari, Saeed
AU - Pourmotabbed, Tayebeh
AU - Zand, Ramin
N1 - Publisher Copyright:
© 2016 Shahjouei, Ansari, Pourmotabbed and Zand.
PY - 2016/6/27
Y1 - 2016/6/27
N2 - Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.
AB - Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.
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U2 - 10.3389/fmolb.2016.00025
DO - 10.3389/fmolb.2016.00025
M3 - Review article
AN - SCOPUS:85037047337
SN - 2296-889X
VL - 3
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
IS - JUN
M1 - 25
ER -