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PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance
James E. Klaunig
, Michael A. Babich
, Karl P. Baetcke
, Jon C. Cook
, J. Chris Corton
, Raymond M. David
, John G. DeLuca
, David Y. Lai
, Richard H. McKee
,
Jeffrey M. Peters
, Ruth A. Roberts
, Penelope A. Fenner-Crisp
Veterinary and Biomedical Sciences
Penn State Cancer Institute
Huck Institutes of the Life Sciences
Cancer Institute, Mechanisms of Carcinogenesis
Research output
:
Contribution to journal
›
Review article
›
peer-review
578
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Scopus citations
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Dive into the research topics of 'PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance'. Together they form a unique fingerprint.
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Keyphrases
Tumor
100%
Rodents
100%
Mode of Action
100%
Peroxisome Proliferator-activated Receptor
100%
Human Relevance
100%
Action Relevance
100%
Liver
33%
Peroxisome Proliferation
33%
Alpha Activation
33%
Hepatocytes
22%
Bioassay Data
22%
Fatty Acid Oxidation
22%
Rodent Liver
22%
Animal Tumors
22%
Natural Products
11%
Mouse Strain
11%
Metabolism
11%
Tumor Subtype
11%
Lipid Metabolism
11%
Oxidative Stress
11%
Trichloroethylene
11%
Hydrogen Peroxide
11%
Kupffer Cells
11%
Cell Proliferation
11%
Mouse Liver
11%
Cell Apoptosis
11%
Cell-mediated
11%
Herbicide
11%
Primates
11%
Human Sources
11%
Nuclear Receptor
11%
Species Differences
11%
Rat Liver
11%
Phthalates
11%
Pesticides
11%
Laboratory Animals
11%
Human Data
11%
Bile
11%
Cell Tumor
11%
Direct Inhibitors
11%
State of Science
11%
Volume Density
11%
Peroxisome Proliferators
11%
Plasticizer
11%
Energy Homeostasis
11%
Chlorinated Solvents
11%
Peroxisome
11%
Oxidation System
11%
Perchloroethylene
11%
Clonal Expansion
11%
Tumor-associated
11%
Animal Carcinogen
11%
Drug Substance
11%
Non-genotoxic
11%
Rat Testis
11%
Rat Pancreas
11%
Liver Rat
11%
Rat Strains
11%
Leydig Cell Tumor
11%
Pancreatic Acinar Cells
11%
Rat Leydig Cells
11%
Animal Sources
11%
Human Relevance Framework
11%
Chlorinated Paraffins
11%
Testosterone Biosynthesis
11%
Hypolipidemic
11%
Animal Mode
11%
Developing Mode
11%
Action Information
11%
New Humanities
11%
Pharmacology, Toxicology and Pharmaceutical Science
Mode of Action
100%
Peroxisome Proliferator Activated Receptor Alpha
66%
Rat
55%
Neoplasm
33%
Fatty Acid
22%
Bioassay
22%
Carcinogen
11%
Natural Product
11%
Hydrogen Peroxide
11%
Herbicide
11%
Experimental Animal
11%
Phthalic Acid
11%
Peroxisome Proliferator
11%
Hormone Receptor
11%
Plasticizer
11%
Trichloroethylene
11%
Tetrachloroethylene
11%
Mouse Strain
11%
Lipid
11%
Hormone Precursor
11%
Hypolipemia
11%
Testosterone
11%
Rat Strain
11%