TY - JOUR
T1 - PPARα mediates peroxisome proliferator-induced transcriptional repression of nonperoxisomal gene expression in mouse
AU - Motojima, Kiyoto
AU - Peters, Jeffrey Maurice
AU - Gonzalez, Frank J.
PY - 1997/1/3
Y1 - 1997/1/3
N2 - The strain difference, peroxisome proliferator specificity and role of PPARα in peroxisome proliferator-induced transcriptional repression of nonperoxisomal transthyretin and α(2u)-globulin genes were examined. The genes were repressed by four peroxisome proliferators in all seven mouse strains tested. The extent of repression was strongly dependent on both the mouse strains and type of proliferator, although the mRNA levels of PPARα and its partner in heterodimerization, RXRα were not different. The role of PPARα in repression was confirmed by the finding that PPARα-null mice were not responsive to transcriptional repression. These results indicate that PPARα plays an obligatory role in transcription of various genes, some of which are not related to lipid metabolism.
AB - The strain difference, peroxisome proliferator specificity and role of PPARα in peroxisome proliferator-induced transcriptional repression of nonperoxisomal transthyretin and α(2u)-globulin genes were examined. The genes were repressed by four peroxisome proliferators in all seven mouse strains tested. The extent of repression was strongly dependent on both the mouse strains and type of proliferator, although the mRNA levels of PPARα and its partner in heterodimerization, RXRα were not different. The role of PPARα in repression was confirmed by the finding that PPARα-null mice were not responsive to transcriptional repression. These results indicate that PPARα plays an obligatory role in transcription of various genes, some of which are not related to lipid metabolism.
UR - http://www.scopus.com/inward/record.url?scp=0031550228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031550228&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1996.5906
DO - 10.1006/bbrc.1996.5906
M3 - Article
C2 - 9020034
AN - SCOPUS:0031550228
SN - 0006-291X
VL - 230
SP - 155
EP - 158
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -