Abstract
Postsynaptic clustering of GABAA (type A γ-aminobutyric acid) receptors is essential to ensure proper function of GABAergic synapses. This process is initiated during synapse formation and is maintained throughout life. The tubulin-associated protein gephyrin is required for clustering of GABAA receptors, but its specific role in this process is not understood. A second protein associated selectively with GABAA receptors at postsynaptic sites is dystrophin. It is present in a subset of GABAergic synapses along with several partners, forming the dystrophin-associated protein complex. In this review, we discuss recent advances in the role of neuronal activity and trans-synaptic signaling for the clustering of gephyrin and dystrophin during synaptogenesis and on the role of these proteins for plasticity and maintenance of mature synapses.
Original language | English (US) |
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Pages (from-to) | 889-892 |
Number of pages | 4 |
Journal | Biochemical Society transactions |
Volume | 31 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2003 |
All Science Journal Classification (ASJC) codes
- Biochemistry