TY - JOUR
T1 - Pre-procedural antibiotics for endoscopic urological procedures
T2 - Initial experience in individuals with spinal cord injury and asymptomatic bacteriuria
AU - Chong, Julio T.
AU - Klausner, Adam P.
AU - Petrossian, Albert
AU - Byrne, Michael D.
AU - Moore, Jewel R.
AU - Goetz, Lance L.
AU - Gater, David R.
AU - Grob, B. Mayer
N1 - Publisher Copyright:
© The Academy of Spinal Cord Injury Professionals, Inc. 2015.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Objective: The objective of this study was to compare the safety, efficacy, quality-of-life impact, and costs of a single dose or a longer course of pre-procedural antibiotics prior to elective endoscopic urological procedures in individuals with spinal cord injury and disorders (SCI/D) and asymptomatic bacteriuria. Design: A prospective observational study. Setting: Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA. Participants: Sixty persons with SCI/D and asymptomatic bacteriuria scheduled to undergo elective endoscopic urological procedures. Interventions: A single pre-procedural dose of antibiotics vs. a 3-5-day course of pre-procedural antibiotics. Outcome measures: Objective and subjective measures of health, costs, and quality of life. Results: There were no significant differences in vital signs, leukocytosis, adverse events, and overall satisfaction in individuals who received short-course vs. long-course antibiotics. There was a significant decrease in antibiotic cost (33.1 ± 47.6 vs. 3.6 ± 6.1 US$, P = 0.01) for individuals in the short-course group. In addition, there was greater pre-procedural anxiety (18 vs. 0%, P < 0.05) for individuals who received long-course antibiotics. Conclusion: SCI/D individuals with asymptomatic bacteriuria may be able to safely undergo most endoscopic urological procedures with a single dose of pre-procedural antibiotics. However, further research is required and even appropriate pre-procedural antibiotics may not prevent severe infections.
AB - Objective: The objective of this study was to compare the safety, efficacy, quality-of-life impact, and costs of a single dose or a longer course of pre-procedural antibiotics prior to elective endoscopic urological procedures in individuals with spinal cord injury and disorders (SCI/D) and asymptomatic bacteriuria. Design: A prospective observational study. Setting: Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA. Participants: Sixty persons with SCI/D and asymptomatic bacteriuria scheduled to undergo elective endoscopic urological procedures. Interventions: A single pre-procedural dose of antibiotics vs. a 3-5-day course of pre-procedural antibiotics. Outcome measures: Objective and subjective measures of health, costs, and quality of life. Results: There were no significant differences in vital signs, leukocytosis, adverse events, and overall satisfaction in individuals who received short-course vs. long-course antibiotics. There was a significant decrease in antibiotic cost (33.1 ± 47.6 vs. 3.6 ± 6.1 US$, P = 0.01) for individuals in the short-course group. In addition, there was greater pre-procedural anxiety (18 vs. 0%, P < 0.05) for individuals who received long-course antibiotics. Conclusion: SCI/D individuals with asymptomatic bacteriuria may be able to safely undergo most endoscopic urological procedures with a single dose of pre-procedural antibiotics. However, further research is required and even appropriate pre-procedural antibiotics may not prevent severe infections.
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U2 - 10.1179/2045772313Y.0000000185
DO - 10.1179/2045772313Y.0000000185
M3 - Article
C2 - 24621035
AN - SCOPUS:84924260335
SN - 1079-0268
VL - 38
SP - 187
EP - 192
JO - Journal of Spinal Cord Medicine
JF - Journal of Spinal Cord Medicine
IS - 2
ER -