Pre-vs. Post-synaptic Effect

Nicholas Graziane; Yan Dong

doi:10.1007/978-1-0716-2589-7_15

Pre-vs. Post-synaptic Effect

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A commonly pursued goal in studying synaptic plasticity is to determine whether synaptic inputs undergo presynaptic and/or postsynaptic alterations following a stimulus and how these alterations affect the firing properties of the innervated neuron. In this chapter, we continue to discuss approaches that can be implemented to test presynaptic mechanisms of plasticity. In addition, we explain modifications that can occur in the postsynaptic cell affecting the intrinsic membrane excitability. Related to this, we discuss the voltage-gated channels that regulate the intrinsic membrane excitability and how these channels contribute to EPSP summation at the soma and back-propagating action potentials. We conclude this chapter with approaches that can be used to measure the intrinsic membrane excitability.

Original language	English (US)
Title of host publication	Neuromethods
Publisher	Humana Press Inc.
Pages	177-188
Number of pages	12
DOIs	https://doi.org/10.1007/978-1-0716-2589-7_15
State	Published - 2022

Publication series

Name	Neuromethods
Volume	187
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-0716-2589-7_15

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title = "Pre-vs. Post-synaptic Effect",

abstract = "A commonly pursued goal in studying synaptic plasticity is to determine whether synaptic inputs undergo presynaptic and/or postsynaptic alterations following a stimulus and how these alterations affect the firing properties of the innervated neuron. In this chapter, we continue to discuss approaches that can be implemented to test presynaptic mechanisms of plasticity. In addition, we explain modifications that can occur in the postsynaptic cell affecting the intrinsic membrane excitability. Related to this, we discuss the voltage-gated channels that regulate the intrinsic membrane excitability and how these channels contribute to EPSP summation at the soma and back-propagating action potentials. We conclude this chapter with approaches that can be used to measure the intrinsic membrane excitability.",

author = "Nicholas Graziane and Yan Dong",

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AB - A commonly pursued goal in studying synaptic plasticity is to determine whether synaptic inputs undergo presynaptic and/or postsynaptic alterations following a stimulus and how these alterations affect the firing properties of the innervated neuron. In this chapter, we continue to discuss approaches that can be implemented to test presynaptic mechanisms of plasticity. In addition, we explain modifications that can occur in the postsynaptic cell affecting the intrinsic membrane excitability. Related to this, we discuss the voltage-gated channels that regulate the intrinsic membrane excitability and how these channels contribute to EPSP summation at the soma and back-propagating action potentials. We conclude this chapter with approaches that can be used to measure the intrinsic membrane excitability.

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PB - Humana Press Inc.

ER -

Pre-vs. Post-synaptic Effect

Abstract

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