TY - JOUR
T1 - Predicting gas chromatographic separation and stationary-phase selectivity using computer modeling
AU - Dorman, Frank L.
AU - Schettler, Paul D.
AU - English, Christopher M.
AU - Patwardhant, Dinesh V.
PY - 2002/5/1
Y1 - 2002/5/1
N2 - A computer modeling technique has been developed which allows for the prediction of chromatographic separation and stationary-phase selectivity. This technique enables development of application-specific gas chromatographic columns by allowing for the simultaneous optimization of physical dimensions, flow and temperature programs, and stationary-phase composition. Stationary-phase selectivity is the most powerful tool available to achieve a separation; however most commercially available columns were not designed to have a selectivity specific to the separations for which they are used. The techniques described in this paper were developed to address this need.
AB - A computer modeling technique has been developed which allows for the prediction of chromatographic separation and stationary-phase selectivity. This technique enables development of application-specific gas chromatographic columns by allowing for the simultaneous optimization of physical dimensions, flow and temperature programs, and stationary-phase composition. Stationary-phase selectivity is the most powerful tool available to achieve a separation; however most commercially available columns were not designed to have a selectivity specific to the separations for which they are used. The techniques described in this paper were developed to address this need.
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U2 - 10.1021/ac0110496
DO - 10.1021/ac0110496
M3 - Article
C2 - 12033317
AN - SCOPUS:0036569883
SN - 0003-2700
VL - 74
SP - 2133
EP - 2138
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 9
ER -