Prediction of heart transplant rejection with a breath test for markers of oxidative stress

Michael Phillips; John P. Boehmer; Renee N. Cataneo; Taseer Cheema; Howard J. Eisen; John T. Fallon; Peter E. Fisher; Alan Gass; Joel Greenberg; Jon Kobashigawa; Donna Mancini; Barry Rayburn; Mark J. Zucker

doi:10.1016/j.amjcard.2004.08.052

Prediction of heart transplant rejection with a breath test for markers of oxidative stress

Michael Phillips, John P. Boehmer, Renee N. Cataneo, Taseer Cheema, Howard J. Eisen, John T. Fallon, Peter E. Fisher, Alan Gass, Joel Greenberg, Jon Kobashigawa, Donna Mancini, Barry Rayburn, Mark J. Zucker

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The Heart Allograft Rejection: Detection with Breath Alkanes in Low Levels study evaluated a breath test for oxidative stress in heart transplant recipients, and we report here a mathematical model predicting the probability of grade 3 rejection. The breath test divided the heart transplant recipients into 3 groups: positive for grade 3 rejection, negative for grade 3 rejection, and intermediate. The test was 100% sensitive for grade 3 heart transplant rejection when the p value was ≥0.98, and 100% specific when the p value was ≤0.058; in the intermediate group, the breath test determined the probability of grade 3 rejection and the predictive value of the result.

Original language	English (US)
Pages (from-to)	1593-1594
Number of pages	2
Journal	American Journal of Cardiology
Volume	94
Issue number	12
DOIs	https://doi.org/10.1016/j.amjcard.2004.08.052
State	Published - Dec 15 2004

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2004.08.052

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Phillips, M., Boehmer, J. P., Cataneo, R. N., Cheema, T., Eisen, H. J., Fallon, J. T., Fisher, P. E., Gass, A., Greenberg, J., Kobashigawa, J., Mancini, D., Rayburn, B., & Zucker, M. J. (2004). Prediction of heart transplant rejection with a breath test for markers of oxidative stress. American Journal of Cardiology, 94(12), 1593-1594. https://doi.org/10.1016/j.amjcard.2004.08.052

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title = "Prediction of heart transplant rejection with a breath test for markers of oxidative stress",

abstract = "The Heart Allograft Rejection: Detection with Breath Alkanes in Low Levels study evaluated a breath test for oxidative stress in heart transplant recipients, and we report here a mathematical model predicting the probability of grade 3 rejection. The breath test divided the heart transplant recipients into 3 groups: positive for grade 3 rejection, negative for grade 3 rejection, and intermediate. The test was 100% sensitive for grade 3 heart transplant rejection when the p value was ≥0.98, and 100% specific when the p value was ≤0.058; in the intermediate group, the breath test determined the probability of grade 3 rejection and the predictive value of the result.",

author = "Michael Phillips and Boehmer, {John P.} and Cataneo, {Renee N.} and Taseer Cheema and Eisen, {Howard J.} and Fallon, {John T.} and Fisher, {Peter E.} and Alan Gass and Joel Greenberg and Jon Kobashigawa and Donna Mancini and Barry Rayburn and Zucker, {Mark J.}",

year = "2004",

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doi = "10.1016/j.amjcard.2004.08.052",

language = "English (US)",

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Phillips, M, Boehmer, JP, Cataneo, RN, Cheema, T, Eisen, HJ, Fallon, JT, Fisher, PE, Gass, A, Greenberg, J, Kobashigawa, J, Mancini, D, Rayburn, B & Zucker, MJ 2004, 'Prediction of heart transplant rejection with a breath test for markers of oxidative stress', American Journal of Cardiology, vol. 94, no. 12, pp. 1593-1594. https://doi.org/10.1016/j.amjcard.2004.08.052

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T1 - Prediction of heart transplant rejection with a breath test for markers of oxidative stress

AU - Phillips, Michael

AU - Boehmer, John P.

AU - Cataneo, Renee N.

AU - Cheema, Taseer

AU - Eisen, Howard J.

AU - Fallon, John T.

AU - Fisher, Peter E.

AU - Gass, Alan

AU - Greenberg, Joel

AU - Kobashigawa, Jon

AU - Mancini, Donna

AU - Rayburn, Barry

AU - Zucker, Mark J.

PY - 2004/12/15

Y1 - 2004/12/15

N2 - The Heart Allograft Rejection: Detection with Breath Alkanes in Low Levels study evaluated a breath test for oxidative stress in heart transplant recipients, and we report here a mathematical model predicting the probability of grade 3 rejection. The breath test divided the heart transplant recipients into 3 groups: positive for grade 3 rejection, negative for grade 3 rejection, and intermediate. The test was 100% sensitive for grade 3 heart transplant rejection when the p value was ≥0.98, and 100% specific when the p value was ≤0.058; in the intermediate group, the breath test determined the probability of grade 3 rejection and the predictive value of the result.

AB - The Heart Allograft Rejection: Detection with Breath Alkanes in Low Levels study evaluated a breath test for oxidative stress in heart transplant recipients, and we report here a mathematical model predicting the probability of grade 3 rejection. The breath test divided the heart transplant recipients into 3 groups: positive for grade 3 rejection, negative for grade 3 rejection, and intermediate. The test was 100% sensitive for grade 3 heart transplant rejection when the p value was ≥0.98, and 100% specific when the p value was ≤0.058; in the intermediate group, the breath test determined the probability of grade 3 rejection and the predictive value of the result.

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JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 12

ER -

Prediction of heart transplant rejection with a breath test for markers of oxidative stress

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