TY - JOUR
T1 - Predictors of large and small artery elasticity in healthy subjects from 9 to 89 years old
AU - Gardner, Andrew W.
AU - Parker, Donald E.
N1 - Funding Information:
acknowledgments:This research was supported by the National Center on Minority Health and Health Disparities (P20-MD-000528-05), and by the University of Oklahoma Health Sciences Center General Clinical Research Center grant (M01-RR-14467), sponsored by the National Center for Research Resources from the National Institutes of Health. The final peer-reviewed version of this manuscript is subject to the NIH Public access Policy, and will be submitted to PubMed Central.
PY - 2011/5
Y1 - 2011/5
N2 - BackgroundWe identified demographic variables, cardiovascular risk factors, and ambulatory activity measures that predict large and small artery elasticity in apparently healthy subjects between 9 and 89 years of age.MethodsA total of 480 subjects were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), demographic measures, cardiovascular risk factors, and daily ambulation during 7 consecutive days. All possible regression and Mallow's Cp were used to select multivariate models for prediction of LAEI and SAEI.ResultsIn subjects 20 years of age and younger, LAEI model (R2 = 0.25, P <0.001) included age, average ambulatory cadence, and obesity. SAEI model (R2 = 0.39, P <0.001) contained body mass index (BMI), maximum daily ambulatory cadence for 30 continuous min, age, and total ambulatory strides. In subjects between 21 and 50 years, LAEI model (R2 = 0.41, P <0.001) included systolic blood pressure (SBP), gender, race, and diastolic blood pressure (DBP). SAEI model (R2 = 0.42, P <0.001) contained gender, BMI, DBP, race, dyslipidemia, and SBP. In subjects older than 50 years, LAEI model (R2 = 0.54, P <0.001) included SBP, gender, age, and BMI. SAEI model (R2 = 0.45, P <0.001) contained gender, age, BMI, DBP, current smoking, and SBP.ConclusionsDaily ambulatory activity, particularly cadence of 30 continuous min of ambulation, is positively associated with arterial elasticity in children and adolescents. In contrast, the predominant factors related to the decline in arterial elasticity in adults are blood pressure and age.
AB - BackgroundWe identified demographic variables, cardiovascular risk factors, and ambulatory activity measures that predict large and small artery elasticity in apparently healthy subjects between 9 and 89 years of age.MethodsA total of 480 subjects were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), demographic measures, cardiovascular risk factors, and daily ambulation during 7 consecutive days. All possible regression and Mallow's Cp were used to select multivariate models for prediction of LAEI and SAEI.ResultsIn subjects 20 years of age and younger, LAEI model (R2 = 0.25, P <0.001) included age, average ambulatory cadence, and obesity. SAEI model (R2 = 0.39, P <0.001) contained body mass index (BMI), maximum daily ambulatory cadence for 30 continuous min, age, and total ambulatory strides. In subjects between 21 and 50 years, LAEI model (R2 = 0.41, P <0.001) included systolic blood pressure (SBP), gender, race, and diastolic blood pressure (DBP). SAEI model (R2 = 0.42, P <0.001) contained gender, BMI, DBP, race, dyslipidemia, and SBP. In subjects older than 50 years, LAEI model (R2 = 0.54, P <0.001) included SBP, gender, age, and BMI. SAEI model (R2 = 0.45, P <0.001) contained gender, age, BMI, DBP, current smoking, and SBP.ConclusionsDaily ambulatory activity, particularly cadence of 30 continuous min of ambulation, is positively associated with arterial elasticity in children and adolescents. In contrast, the predominant factors related to the decline in arterial elasticity in adults are blood pressure and age.
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U2 - 10.1038/ajh.2011.5
DO - 10.1038/ajh.2011.5
M3 - Article
C2 - 21293385
AN - SCOPUS:79954752779
SN - 0895-7061
VL - 24
SP - 599
EP - 605
JO - American journal of hypertension
JF - American journal of hypertension
IS - 5
ER -