TY - JOUR
T1 - Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events
AU - for the National Emergency Airway Registry for Neonates (NEAR4NEOS) Investigators
AU - Ozawa, Yuri
AU - Ades, Anne
AU - Foglia, Elizabeth E.
AU - DeMeo, Stephen
AU - Barry, James
AU - Sawyer, Taylor
AU - Singh, Neetu
AU - Glass, Kristen
AU - Jung, Philipp
AU - Quek, Bin Huey
AU - Johnston, Lindsay
AU - Kim, Jae
AU - Napolitano, Natalie
AU - Shults, Justine
AU - Nadkarni, Vinay M.
AU - Nishisaki, Akira
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Objective: To determine the impact of premedication for tracheal intubation (TI) on adverse TI associated events, severe oxygen desaturations, and first attempt success Study design: Retrospective cohort study in neonatal intensive care units (NICU) participating in the National Emergency Airway Registry for Neonates from 10/2014 to 6/2017. Premedication for TI was categorized as sedation with neuromuscular blockade, sedation only, or no medication. Results: 2260 TIs were reported from 11 NICUs. Adverse TI associated events occurred less often in sedation with neuromuscular blockade group (10%) as compared to sedation only (29%), or no medication group (23%), p < 0.001. The adjusted odds ratio (aOR) for adverse TI associated events were: sedation with neuromuscular blockade aOR 0.48 (95%CI 0.34–0.65, p < 0.001) compared to no medication. Conclusion: Use of sedation with neuromuscular blockade was associated with favorable TI outcomes. This study supports the recommendation for the standard use of sedation with neuromuscular blockade in non-emergency TIs.
AB - Objective: To determine the impact of premedication for tracheal intubation (TI) on adverse TI associated events, severe oxygen desaturations, and first attempt success Study design: Retrospective cohort study in neonatal intensive care units (NICU) participating in the National Emergency Airway Registry for Neonates from 10/2014 to 6/2017. Premedication for TI was categorized as sedation with neuromuscular blockade, sedation only, or no medication. Results: 2260 TIs were reported from 11 NICUs. Adverse TI associated events occurred less often in sedation with neuromuscular blockade group (10%) as compared to sedation only (29%), or no medication group (23%), p < 0.001. The adjusted odds ratio (aOR) for adverse TI associated events were: sedation with neuromuscular blockade aOR 0.48 (95%CI 0.34–0.65, p < 0.001) compared to no medication. Conclusion: Use of sedation with neuromuscular blockade was associated with favorable TI outcomes. This study supports the recommendation for the standard use of sedation with neuromuscular blockade in non-emergency TIs.
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U2 - 10.1038/s41372-019-0367-0
DO - 10.1038/s41372-019-0367-0
M3 - Article
C2 - 30940929
AN - SCOPUS:85063742702
SN - 0743-8346
VL - 39
SP - 848
EP - 856
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 6
ER -