Preoperative serum albumin is associated with mortality and complications after radical cystectomy

Tullika Garg, Ling Y. Chen, Philip H. Kim, Philip T. Zhao, Harry W. Herr, S. Machele Donat

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Objective To determine the association between preoperative serum albumin and mortality and postoperative complications after radical cystectomy (RC) and urinary diversion. Patients and Methods We conducted a retrospective review of 1097 RCs performed for the treatment of bladder cancer between 1992 and 2005. All data were entered prospectively into a hospital-based complications database. We used multivariable logistic regression to assess the association between preoperative serum albumin and complications and mortality ≤90 days of RC, while controlling for preoperative patient and disease characteristics. Results Low preoperative serum albumin was identified in 14% of the cohort. Preoperative serum albumin was a predictor of postoperative complications (adjusted odds ratio [OR] per unit increase in albumin: 0.61, 95% confidence interval [CI] 0.42-0.90) and 90-day mortality (OR 0.33, 95% CI 0.14-0.75) when controlling for sex, race, age-adjusted Charlson score, body mass index, prior history of abdominal surgery, clinical stage, and neoadjuvant chemotherapy. As serum albumin decreased, the risk of complications and mortality increased. Conclusions In addition to age-adjusted Charlson score, low preoperative serum albumin is a significant predictor of complications and mortality after RC. Serum albumin testing can be used to identify individuals at high-risk of morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)918-923
Number of pages6
JournalBJU International
Volume113
Issue number6
DOIs
StatePublished - Jun 2014

All Science Journal Classification (ASJC) codes

  • Urology

Fingerprint

Dive into the research topics of 'Preoperative serum albumin is associated with mortality and complications after radical cystectomy'. Together they form a unique fingerprint.

Cite this