Preparation of quantum dot-nanogel hybrid nanoparticle and its function

Urara Hasegawa, Takashi Hirano, Kazunari Akiyoshi

Research output: Contribution to conferencePaperpeer-review


We report here a novel carrier of quantum dots (QDs) for live cell imaging. Monodisperse hybrid nanoparticles (38 nm in diameter) were prepared by simple mixing of quantum dots and nanogels of cholesteryl-bearing pullulan (CHP) modified with amino groups (CHPNH2). These nanoparticles were effectively internalized into HeLa cells. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. In additon, the internalization of QDs with cells was controlled by the amino-group content of CHPNH2 nanogel. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

Original languageEnglish (US)
Number of pages1
StatePublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005


Conference54th SPSJ Annual Meeting 2005

All Science Journal Classification (ASJC) codes

  • General Engineering


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