Preparation of quantum dot-nanogel hybrid nanoparticle and its function

Urara Hasegawa; Takashi Hirano; Kazunari Akiyoshi

Preparation of quantum dot-nanogel hybrid nanoparticle and its function

Urara Hasegawa, Takashi Hirano, Kazunari Akiyoshi

Materials Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We report here a novel carrier of quantum dots (QDs) for live cell imaging. Monodisperse hybrid nanoparticles (38 nm in diameter) were prepared by simple mixing of quantum dots and nanogels of cholesteryl-bearing pullulan (CHP) modified with amino groups (CHPNH₂). These nanoparticles were effectively internalized into HeLa cells. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. In additon, the internalization of QDs with cells was controlled by the amino-group content of CHPNH₂ nanogel. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

Original language	English (US)
Pages	2184
Number of pages	1
State	Published - 2005
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: May 25 2005 → May 27 2005

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	5/25/05 → 5/27/05

All Science Journal Classification (ASJC) codes

General Engineering

Cite this

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title = "Preparation of quantum dot-nanogel hybrid nanoparticle and its function",

abstract = "We report here a novel carrier of quantum dots (QDs) for live cell imaging. Monodisperse hybrid nanoparticles (38 nm in diameter) were prepared by simple mixing of quantum dots and nanogels of cholesteryl-bearing pullulan (CHP) modified with amino groups (CHPNH2). These nanoparticles were effectively internalized into HeLa cells. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. In additon, the internalization of QDs with cells was controlled by the amino-group content of CHPNH2 nanogel. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.",

author = "Urara Hasegawa and Takashi Hirano and Kazunari Akiyoshi",

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T1 - Preparation of quantum dot-nanogel hybrid nanoparticle and its function

AU - Hasegawa, Urara

AU - Hirano, Takashi

AU - Akiyoshi, Kazunari

PY - 2005

Y1 - 2005

N2 - We report here a novel carrier of quantum dots (QDs) for live cell imaging. Monodisperse hybrid nanoparticles (38 nm in diameter) were prepared by simple mixing of quantum dots and nanogels of cholesteryl-bearing pullulan (CHP) modified with amino groups (CHPNH2). These nanoparticles were effectively internalized into HeLa cells. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. In additon, the internalization of QDs with cells was controlled by the amino-group content of CHPNH2 nanogel. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

AB - We report here a novel carrier of quantum dots (QDs) for live cell imaging. Monodisperse hybrid nanoparticles (38 nm in diameter) were prepared by simple mixing of quantum dots and nanogels of cholesteryl-bearing pullulan (CHP) modified with amino groups (CHPNH2). These nanoparticles were effectively internalized into HeLa cells. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. In additon, the internalization of QDs with cells was controlled by the amino-group content of CHPNH2 nanogel. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

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M3 - Paper

AN - SCOPUS:33645646962

SP - 2184

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Preparation of quantum dot-nanogel hybrid nanoparticle and its function

Abstract

Conference

All Science Journal Classification (ASJC) codes

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