TY - JOUR
T1 - Preshunt liver function remains the prominent determinant of survival after portasystemic shunting
AU - Cowgill, Sarah M.
AU - Carey, Elizabeth
AU - Villadolid, Desiree
AU - Al-Saadi, Sam
AU - Zervos, Emmanuel E.
AU - Rosemurgy, Alexander S.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Background: Forty-five years after the development of the Child classification, we sought to determine if hepatic function is still a primary determinant between short-term and long-term survival after portasystemic shunting. Methods: One hundred forty-six patients underwent small-diameter prosthetic H-graft portacaval shunting (HGPCS). The patients were stratified into 2 groups: those surviving less than 5 years and those surviving more than 5 years. Preoperative data determined Child class and model for end-stage liver disease (MELD) score. Results: Ninety-four (64%) patients were short-term and 52 (36%) patients were long-term survivors. No significant differences in the cause of cirrhosis, presence of ascites, encephalopathy, or emergency operations were noted between short- and long-term survivors. Preshunt MELD scores were significantly greater with short-term survivors, although actual survival was superior to predicted survival by MELD. Child class was inferior for short-term survivors. Child class and MELD score significantly correlated with survival after portasystemic shunting. Conclusions: Long-term survival after HGPCS is possible even with severe hepatic dysfunction; however, actual survival is superior to predicted survival. Hepatic dysfunction, as denoted by Child class and MELD, still remains a primary determinant of survival after portasystemic shunting.
AB - Background: Forty-five years after the development of the Child classification, we sought to determine if hepatic function is still a primary determinant between short-term and long-term survival after portasystemic shunting. Methods: One hundred forty-six patients underwent small-diameter prosthetic H-graft portacaval shunting (HGPCS). The patients were stratified into 2 groups: those surviving less than 5 years and those surviving more than 5 years. Preoperative data determined Child class and model for end-stage liver disease (MELD) score. Results: Ninety-four (64%) patients were short-term and 52 (36%) patients were long-term survivors. No significant differences in the cause of cirrhosis, presence of ascites, encephalopathy, or emergency operations were noted between short- and long-term survivors. Preshunt MELD scores were significantly greater with short-term survivors, although actual survival was superior to predicted survival by MELD. Child class was inferior for short-term survivors. Child class and MELD score significantly correlated with survival after portasystemic shunting. Conclusions: Long-term survival after HGPCS is possible even with severe hepatic dysfunction; however, actual survival is superior to predicted survival. Hepatic dysfunction, as denoted by Child class and MELD, still remains a primary determinant of survival after portasystemic shunting.
UR - http://www.scopus.com/inward/record.url?scp=33750330221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750330221&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2006.08.007
DO - 10.1016/j.amjsurg.2006.08.007
M3 - Article
C2 - 17071194
AN - SCOPUS:33750330221
SN - 0002-9610
VL - 192
SP - 617
EP - 621
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 5 SPEC. ISS.
ER -