Abstract
Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.
Original language | English (US) |
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Pages (from-to) | 149-152 |
Number of pages | 4 |
Journal | Brain research |
Volume | 683 |
Issue number | 1 |
DOIs | |
State | Published - Jun 12 1995 |
All Science Journal Classification (ASJC) codes
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology