Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord

Michael K.C. Wong; Janeen M. Hill; Marc P. Kaufman

doi:10.1016/0006-8993(95)00351-P

Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord

Michael K.C. Wong
, Janeen M. Hill
, Marc P. Kaufman

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L₇ dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.

Original language	English (US)
Pages (from-to)	149-152
Number of pages	4
Journal	Brain research
Volume	683
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(95)00351-P
State	Published - Jun 12 1995

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(95)00351-P

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@article{685e8886b6574c1fb9bdd8e1f23a6f8d,

title = "Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord",

abstract = "Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.",

author = "Wong, \{Michael K.C.\} and Hill, \{Janeen M.\} and Kaufman, \{Marc P.\}",

note = "Funding Information: Finally, we found no evidence that microinjectiono f NMDA into the superficiall aminaei ncreaseda rterialp res-sure. We are unwilling, however,t o exclude a capacityf or NMDA receptorsto evoke a pressore ffectfrom the dorsal horn. Expressiono f this capacitym ay be complex and may depend on the co-activationo f non-NMDA or tachykinin receptors\textbackslash{}[ 19\textbackslash{}]. This research was suported by National Institutes of Health Grant HL30710. We thank Ms. Penny Jones for typing the manuscript.",

year = "1995",

month = jun,

day = "12",

doi = "10.1016/0006-8993(95)00351-P",

language = "English (US)",

volume = "683",

pages = "149--152",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord

AU - Wong, Michael K.C.

AU - Hill, Janeen M.

AU - Kaufman, Marc P.

N1 - Funding Information: Finally, we found no evidence that microinjectiono f NMDA into the superficiall aminaei ncreaseda rterialp res-sure. We are unwilling, however,t o exclude a capacityf or NMDA receptorsto evoke a pressore ffectfrom the dorsal horn. Expressiono f this capacitym ay be complex and may depend on the co-activationo f non-NMDA or tachykinin receptors\[ 19\]. This research was suported by National Institutes of Health Grant HL30710. We thank Ms. Penny Jones for typing the manuscript.

PY - 1995/6/12

Y1 - 1995/6/12

N2 - Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.

AB - Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.

UR - https://www.scopus.com/pages/publications/0029000088

UR - https://www.scopus.com/pages/publications/0029000088#tab=citedBy

U2 - 10.1016/0006-8993(95)00351-P

DO - 10.1016/0006-8993(95)00351-P

M3 - Article

C2 - 7552339

AN - SCOPUS:0029000088

SN - 0006-8993

VL - 683

SP - 149

EP - 152

JO - Brain research

JF - Brain research

IS - 1

ER -

Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord

Abstract

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