Pressure‐flow relationships in the peripheral circulation of the dog with practolol

Jerry Franklin Green; John D. Moore; Edward S. Attix; Robert Zelis

doi:10.1111/j.1440-1681.1975.tb02369.x

Pressure‐flow relationships in the peripheral circulation of the dog with practolol

Jerry Franklin Green, John D. Moore, Edward S. Attix, Robert Zelis

Department of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

1. The influence of practolol (a proposed β₁‐adrenoreceptor antagonist) upon the pressure‐flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by‐pass procedures. 2. Practolol (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective β‐adrenoreceptor antagonist.

Original language	English (US)
Pages (from-to)	17-21
Number of pages	5
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1111/j.1440-1681.1975.tb02369.x
State	Published - Feb 1975

All Science Journal Classification (ASJC) codes

Physiology
Pharmacology
Physiology (medical)

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10.1111/j.1440-1681.1975.tb02369.x

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abstract = "1. The influence of practolol (a proposed β1‐adrenoreceptor antagonist) upon the pressure‐flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by‐pass procedures. 2. Practolol (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective β‐adrenoreceptor antagonist.",

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N2 - 1. The influence of practolol (a proposed β1‐adrenoreceptor antagonist) upon the pressure‐flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by‐pass procedures. 2. Practolol (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective β‐adrenoreceptor antagonist.

AB - 1. The influence of practolol (a proposed β1‐adrenoreceptor antagonist) upon the pressure‐flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by‐pass procedures. 2. Practolol (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective β‐adrenoreceptor antagonist.

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Pressure‐flow relationships in the peripheral circulation of the dog with practolol

Abstract

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