1. The influence of practolol (a proposed β1‐adrenoreceptor antagonist) upon the pressure‐flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by‐pass procedures. 2. Practolol (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective β‐adrenoreceptor antagonist.
|Original language||English (US)|
|Number of pages||5|
|Journal||Clinical and Experimental Pharmacology and Physiology|
|State||Published - Jan 1 1975|
All Science Journal Classification (ASJC) codes
- Physiology (medical)