Presumed sterile endophthalmitis following intravitreal triamcinolone acetonide injection

Darius M. Moshfeghi, Peter K. Kaiser, Sophie J. Bakri, Richard S. Kaiser, Raj K. Maturi, Jonathan E. Sears, Ingrid U. Scott, Jonathan Belmont, Paul M. Beer, Hugo Quiroz-Mercado, William F. Mieler

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BACKGROUND AND OBJECTIVE: To report acute postoperative, presumed sterile endophthalmitis following intravitreal injection of triamcinolone acetonide (IVTA). PATIENTS AND METHODS: Retrospective, interventional, multicenter study of patients with acute sterile endophthalmitis following IVTA injection. RESULTS: A total of 922 IVTA injections were performed. Eight eyes of 8 patients with presumed sterile endophthalmitis were identified. The incidence of endophthalmitis was 0.87% (95% confidence interval, 0.38% to 1.70%). Median time to presentation was 1.5 days (range, 1 to 7 days). Median presenting visual acuity was 20/563 (range, 20/80 to light perception). Initial treatment included vitreous tap and injection of antibiotics (n = 4), pars plana vitrectomy and injection of intravitreal antibiotics (n = 2), or systemic treatment alone with oral levofloxacin (n = 2). Six of 6 intraocular cultures were sterile. Median follow-up was 5.9 months (range, 4 to 9 months) with a median visual acuity at last follow-up of 20/75 (range, 20/40 to counting fingers). CONCLUSIONS: Acute presumed sterile endophthalmitis following IVTA injection presents early in the postoperative period. Visual outcomes are generally good.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging
Issue number1
StatePublished - 2005

All Science Journal Classification (ASJC) codes

  • Surgery
  • Ophthalmology


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