Prevalence of elevated hemoglobin A 2 measured by the CAPILLARYS system

Zhaohai Yang; Carolyn H. Chaffin; Pattye L. Easley; Beatrice Thigpen; Vishnu V.B. Reddy

doi:10.1309/AJCPD0PJGFT0SXMK

Prevalence of elevated hemoglobin A ₂ measured by the CAPILLARYS system

Zhaohai Yang, Carolyn H. Chaffin, Pattye L. Easley, Beatrice Thigpen, Vishnu V.B. Reddy

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Hemoglobin (Hb) A ₂ electrophoresis has been used for prenatal screening for the ß-thalassemia trait (ßTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA ₂ levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA ₂ in the HbAA-pregnancy group had ßTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA ₂ in the HbAA-other group, 5 had ßTT and 2 were normal. The number of patients without ßTT but with HbA ₂ elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA ₂ cutoff (3.5%) was used, only 3 pregnant patients without ßTT had HbA ₂ elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA ₂ elevation had no evidence of ßTT, compared with the nonpregnant group.

Original language	English (US)
Pages (from-to)	42-48
Number of pages	7
Journal	American journal of clinical pathology
Volume	131
Issue number	1
DOIs	https://doi.org/10.1309/AJCPD0PJGFT0SXMK
State	Published - Jan 2009

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine

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10.1309/AJCPD0PJGFT0SXMK

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title = "Prevalence of elevated hemoglobin A 2 measured by the CAPILLARYS system",

abstract = "Hemoglobin (Hb) A 2 electrophoresis has been used for prenatal screening for the {\ss}-thalassemia trait ({\ss}TT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA 2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA 2 in the HbAA-pregnancy group had {\ss}TT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA 2 in the HbAA-other group, 5 had {\ss}TT and 2 were normal. The number of patients without {\ss}TT but with HbA 2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA 2 cutoff (3.5%) was used, only 3 pregnant patients without {\ss}TT had HbA 2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA 2 elevation had no evidence of {\ss}TT, compared with the nonpregnant group.",

author = "Zhaohai Yang and Chaffin, {Carolyn H.} and Easley, {Pattye L.} and Beatrice Thigpen and Reddy, {Vishnu V.B.}",

year = "2009",

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doi = "10.1309/AJCPD0PJGFT0SXMK",

language = "English (US)",

volume = "131",

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journal = "American journal of clinical pathology",

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T1 - Prevalence of elevated hemoglobin A 2 measured by the CAPILLARYS system

AU - Yang, Zhaohai

AU - Chaffin, Carolyn H.

AU - Easley, Pattye L.

AU - Thigpen, Beatrice

AU - Reddy, Vishnu V.B.

PY - 2009/1

Y1 - 2009/1

N2 - Hemoglobin (Hb) A 2 electrophoresis has been used for prenatal screening for the ß-thalassemia trait (ßTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA 2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA 2 in the HbAA-pregnancy group had ßTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA 2 in the HbAA-other group, 5 had ßTT and 2 were normal. The number of patients without ßTT but with HbA 2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA 2 cutoff (3.5%) was used, only 3 pregnant patients without ßTT had HbA 2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA 2 elevation had no evidence of ßTT, compared with the nonpregnant group.

AB - Hemoglobin (Hb) A 2 electrophoresis has been used for prenatal screening for the ß-thalassemia trait (ßTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA 2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA 2 in the HbAA-pregnancy group had ßTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA 2 in the HbAA-other group, 5 had ßTT and 2 were normal. The number of patients without ßTT but with HbA 2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA 2 cutoff (3.5%) was used, only 3 pregnant patients without ßTT had HbA 2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA 2 elevation had no evidence of ßTT, compared with the nonpregnant group.

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JO - American journal of clinical pathology

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Prevalence of elevated hemoglobin A ₂ measured by the CAPILLARYS system

Abstract

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