Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Amanda J. Miller, Lauren E. Stiles, Timothy Sheehan, Rebecca Bascom, Howard P. Levy, Clair A. Francomano, Amy C. Arnold

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

Original languageEnglish (US)
Article number102637
JournalAutonomic Neuroscience: Basic and Clinical
StatePublished - Mar 2020

All Science Journal Classification (ASJC) codes

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome'. Together they form a unique fingerprint.

Cite this