Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Amanda J. Miller; Lauren E. Stiles; Timothy Sheehan; Rebecca Bascom; Howard P. Levy; Clair A. Francomano; Amy C. Arnold

doi:10.1016/j.autneu.2020.102637

Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Amanda J. Miller, Lauren E. Stiles, Timothy Sheehan, Rebecca Bascom, Howard P. Levy, Clair A. Francomano, Amy C. Arnold

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Abstract

Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

Original language	English (US)
Article number	102637
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	224
DOIs	https://doi.org/10.1016/j.autneu.2020.102637
State	Published - Mar 2020

All Science Journal Classification (ASJC) codes

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

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title = "Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome",

abstract = "Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.",

author = "Miller, {Amanda J.} and Stiles, {Lauren E.} and Timothy Sheehan and Rebecca Bascom and Levy, {Howard P.} and Francomano, {Clair A.} and Arnold, {Amy C.}",

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AU - Miller, Amanda J.

AU - Stiles, Lauren E.

AU - Sheehan, Timothy

AU - Bascom, Rebecca

AU - Levy, Howard P.

AU - Francomano, Clair A.

AU - Arnold, Amy C.

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AB - Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

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Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Abstract

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