Prevalence of Systemic Inflammation and Micronutrient Imbalance in Patients with Complex Abdominal Hernias

Abby K. Geletzke, John M. Rinaldi, Brett E. Phillips, Sarah B. Mobley, Jamie Miller, Thomas Dykes, Christopher Hollenbeak, Shannon L. Kelleher, David I. Soybel

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: To determine the prevalence of low-grade inflammation, micronutrient imbalances and associated clinical profiles in patients being evaluated for complex abdominal hernia repair. Methods: Review of 127 consecutive adult patients for evaluation of complex ventral hernias from January 2012 to March 2013. Records were analyzed to determine the prevalence and correlations of clinical risk factors, attributes of hernias identified by computerized tomography, and laboratory indices of metabolism, inflammation and micronutrient imbalances. Results: Strong correlations (p < 0.001) were established for body mass index (BMI) with volume of hernia content and C-reactive protein (CRP) level. CRP levels correlated strongly with red cell distribution width and inversely with zinc (p < 0.01). Evidence of micronutrient imbalance (abnormal zinc or red cell distribution width [RDW]) was observed in 48 %. Conclusions: In this comorbidity-rich population with known variability in surgical outcomes, the prevalence of chronic inflammation and micronutrient deficiency are high enough to warrant systemic preoperative evaluation given their possible effect on wound healing and convalescence. Simple repletion is unlikely to improve outcomes without attention to the biological stresses that are associated with micronutrient imbalance.

Original languageEnglish (US)
Pages (from-to)646-655
Number of pages10
JournalJournal of Gastrointestinal Surgery
Issue number4
StatePublished - Apr 2014

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology


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