Previous lung diseases and lung cancer risk: A pooled analysis from the international lung cancer consortium

Darren R. Brenner, Paolo Boffetta, Eric J. Duell, Heike Bickeböller, Albert Rosenberger, Valerie McCormack, Joshua E. Muscat, Ping Yang, H. Erich Wichmann, Irene Brueske-Hohlfeld, Ann G. Schwartz, Michele L. Cote, Anne Tjonneland, Soren Friis, Loic Le Marchand, Zuo Feng Zhang, Hal Morgenstern, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, David ZaridzePeter Rudnai, Eleonora Fabianova, Lenka Foretova, Vladimir Janout, Vladimir Bencko, Miriam Schejbalova, Paul Brennan, Ioan N. Mates, Philip Lazarus, John K. Field, Olaide Raji, John R. McLaughlin, Geoffrey Liu, John Wiencke, Monica Neri, Donatella Ugolini, Angeline S. Andrew, Qing Lan, Wei Hu, Irene Orlow, Bernard J. Park, Rayjean J. Hung

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations


To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (19842011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95 confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95 CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk 1.48, 95 CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk 1.57, 95 CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.

Original languageEnglish (US)
Pages (from-to)573-585
Number of pages13
JournalAmerican journal of epidemiology
Issue number7
StatePublished - Oct 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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