Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)

T. K. Cooper, K. N. Murray, S. Spagnoli, J. M. Spitsbergen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.

Original languageEnglish (US)
Pages (from-to)388-392
Number of pages5
JournalVeterinary Pathology
Issue number2
StatePublished - Mar 16 2015

All Science Journal Classification (ASJC) codes

  • General Veterinary


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