Pro-gastrin-releasing peptide(31-98) as a tumour marker of small-cell lung cancer: Comparative evaluation with neuron-specific enolase

M. Takada, Y. Kusunoki, N. Masuda, K. Matui, T. Yana, S. Ushijima, K. Iida, K. Tamura, T. Komiya, I. Kawase, N. Kikui, H. Morino, M. Fukuoka

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69 Scopus citations


We attempted to clarify whether serum levels of a carboxy-terminal fragment of ProGRP, ProGRP(31-98), could serve as a more accurate tumour marker in patients with SCLC than neuron-specific enolase (NSE). ProGRP(31-98) and NSE were measured retrospectively in 101 newly diagnosed untreated patients with SCLC, 111 with non-small-cell lung cancer (NSCLC) and 114 patients with non-malignant lung diseases. ProGRP(31-98) and NSE levels were determined using a sandwich enzyme-linked immunosorbent assay. Sensitivity in SCLC patients was 72.3% for ProGRP(31-98) and 62.4% for NSE. Comparing the area under curve (AUC) of 'receiver operator characteristics' of ProGRP(31-98) with that of NSE, ProGRP(31-98) was the more powerful marker in the diagnosis of SCLC (P = 0.0001). Serum levels of ProGRP(31-98) were higher in the 40 patients with extensive disease than in the 61 patients with limited disease (P = 0.0082). ProGRP(31-98) was significantly higher in patients with pure small-cell carcinoma than in patients with mixed small-cell/large-cell carcinoma (P = 0.02). In serial measurement in 16 patients responding to treatment, a high degree of correlation was noted between the decrease in serum. ProGRP(31-98) levels and clinical response during the second week after treatment (P = 0.0045). These results indicate that the determination of serum ProGRP(31-98) levels plays an important role in the diagnosis and treatment of SCLC patients.

Original languageEnglish (US)
Pages (from-to)1227-1232
Number of pages6
JournalBritish Journal of Cancer
Issue number10
StatePublished - 1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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