Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice

Medicine & Life Sciences

• molecular chaperone GRP78 100%
• Cyclic Peptides 91%
• Neoplasms 18%
• Human Umbilical Vein Endothelial Cells 12%
• Protein Domains 11%
• Therapeutics 10%
• Hydrogen Deuterium Exchange-Mass Spectrometry 9%
• Peptidomimetics 8%
• Ligands 8%
• Apoptosis 7%
• Amides 6%
• Caspase 8 6%
• Growth 5%
• Drug Delivery Systems 5%
• Tumor Biomarkers 5%
• Intravenous Administration 5%
• Heterografts 5%
• Membrane Proteins 4%
• Adenosine Triphosphate 4%
• Endothelial Cells 4%
• Amino Acids 4%
• Peptides 3%
• Blood Vessels 3%

Chemical Compounds

• Cyclic Peptide 74%
• Antineoplastic Agent 56%
• Glucose 46%
• Protein 26%
• Peptidomimetic 6%
• Biological Marker 4%
• Amino-Acid Residue 4%
• Ligand 4%
• Amide 3%
• Mass Spectrometry 3%
• Peptide 3%
• Drug 2%
• Reduction 2%