Keyphrases
Amino Acid Substitution
33%
Conserved Residues
33%
Dihydrofolate
33%
Dissociation Rate
33%
Enzyme Product
33%
Escherichia Coli Dihydrofolate Reductase
100%
Fold Increase
33%
Functional Role
100%
Hydride Transfer
33%
Hydrophobic Pocket
33%
Kinetic Behavior
33%
Mutant Enzyme
100%
Opposing Effects
33%
Phenylalanine
100%
Product Complexity
66%
Quantitative Effects
33%
Rate Limiting
33%
Rate-limiting Step
33%
Site-directed mutagenesis
100%
Ternary Complex
33%
Tetrahydrofolate
66%
Ultrafast Dissociation
33%
Biochemistry, Genetics and Molecular Biology
Amino Acid Substitution
25%
Dihydrofolate Reductase
100%
Enzyme
100%
Escherichia coli
100%
Phenylalanine
100%
Site-Directed Mutagenesis
100%
Ternary Complex
25%
Tetrahydrofolic Acid
50%
Wild Type
50%
Chemistry
Dihydrofolates
100%
Tetrahydrofolate
66%
Tetrahydrofolic Acid
66%