Probing when dCas9 tolerates DNA mismatches

Weihua Guan

doi:10.1038/s41551-023-01172-5

Probing when dCas9 tolerates DNA mismatches

Weihua Guan

Electrical Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.

Original language	English (US)
Pages (from-to)	207-208
Number of pages	2
Journal	Nature Biomedical Engineering
Volume	8
Issue number	3
DOIs	https://doi.org/10.1038/s41551-023-01172-5
State	Published - Mar 2024

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

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10.1038/s41551-023-01172-5

Cite this

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abstract = "Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.",

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Probing when dCas9 tolerates DNA mismatches

Abstract

All Science Journal Classification (ASJC) codes

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