Probing when dCas9 tolerates DNA mismatches

Weihua Guan

doi:10.1038/s41551-023-01172-5

Probing when dCas9 tolerates DNA mismatches

Weihua Guan

Electrical Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.

Original language	English (US)
Pages (from-to)	207-208
Number of pages	2
Journal	Nature Biomedical Engineering
Volume	8
Issue number	3
DOIs	https://doi.org/10.1038/s41551-023-01172-5
State	Published - Mar 2024

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

Access to Document

10.1038/s41551-023-01172-5

Cite this

@article{4f47e922dd8a4cacb35fc46c8de3cd8f,

title = "Probing when dCas9 tolerates DNA mismatches",

abstract = "Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.",

author = "Weihua Guan",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2023.",

year = "2024",

month = mar,

doi = "10.1038/s41551-023-01172-5",

language = "English (US)",

volume = "8",

pages = "207--208",

journal = "Nature Biomedical Engineering",

issn = "2157-846X",

publisher = "Nature Research",

number = "3",

}

TY - JOUR

T1 - Probing when dCas9 tolerates DNA mismatches

AU - Guan, Weihua

N1 - Publisher Copyright: © Springer Nature Limited 2023.

PY - 2024/3

Y1 - 2024/3

N2 - Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.

AB - Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.

UR - https://www.scopus.com/pages/publications/85180472184

UR - https://www.scopus.com/inward/citedby.url?scp=85180472184&partnerID=8YFLogxK

U2 - 10.1038/s41551-023-01172-5

DO - 10.1038/s41551-023-01172-5

M3 - Article

C2 - 38135764

AN - SCOPUS:85180472184

SN - 2157-846X

VL - 8

SP - 207

EP - 208

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

IS - 3

ER -

Probing when dCas9 tolerates DNA mismatches

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this