Probiotics against Campylobacter pathogens

Background: The subject matter of this study was to investigate, for the first time, the immediate-preventive effect of probiotics, composed of Bacillus species, in a murine model of Campylobacter infection. Methods: An established model of Campylobacter infection in mice with a defined LD₅₀ was utilized to assess the protective effect of probiotics. Results: The results obtained demonstrate that the level of animal protection, after a single administration of the new probiotics biosporin and subalin, reached 90-100% at LD₅₀ and 80% at LD₁₀₀. Conclusions: Such efficacy of probiotics is considered to be due to their high antagonistic activity against those pathogens registered in vitro. Antagonistic activity of other tested probiotics (bactisubtil and cereobiogen) to different cultures of Campylobacter was not manifested.