Production and application of menaquinone-7 (vitamin K2): a new perspective

Ehsan Mahdinia, Ali Demirci, Aydin Berenjian

Research output: Contribution to journalReview articlepeer-review

58 Citations (SciVal)


Menaquinone-7, a highly valuable member of the vitamin K series, has significant effects on preventing osteoporosis and cardiovascular disease besides its positive effects on blood coagulation. In this review, chemical and biological aspects of menaquinone-7 are briefly summarized followed by a critical review on upstream and downstream processing developments for its production and recovery, including solid versus liquid fermentations, static versus agitated fermentations and online versus post-production recovery. Latest research outcomes for improving industrial scale production of menaquinone-7 are summarized and recommendations are given for areas of future research.

Original languageEnglish (US)
Article number2
JournalWorld Journal of Microbiology and Biotechnology
Issue number1
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Physiology
  • Applied Microbiology and Biotechnology


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