TY - JOUR
T1 - Production and application of menaquinone-7 (vitamin K2)
T2 - a new perspective
AU - Mahdinia, Ehsan
AU - Demirci, Ali
AU - Berenjian, Aydin
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media Dordrecht.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Menaquinone-7, a highly valuable member of the vitamin K series, has significant effects on preventing osteoporosis and cardiovascular disease besides its positive effects on blood coagulation. In this review, chemical and biological aspects of menaquinone-7 are briefly summarized followed by a critical review on upstream and downstream processing developments for its production and recovery, including solid versus liquid fermentations, static versus agitated fermentations and online versus post-production recovery. Latest research outcomes for improving industrial scale production of menaquinone-7 are summarized and recommendations are given for areas of future research.
AB - Menaquinone-7, a highly valuable member of the vitamin K series, has significant effects on preventing osteoporosis and cardiovascular disease besides its positive effects on blood coagulation. In this review, chemical and biological aspects of menaquinone-7 are briefly summarized followed by a critical review on upstream and downstream processing developments for its production and recovery, including solid versus liquid fermentations, static versus agitated fermentations and online versus post-production recovery. Latest research outcomes for improving industrial scale production of menaquinone-7 are summarized and recommendations are given for areas of future research.
UR - https://www.scopus.com/pages/publications/84994875729
UR - https://www.scopus.com/pages/publications/84994875729#tab=citedBy
U2 - 10.1007/s11274-016-2169-2
DO - 10.1007/s11274-016-2169-2
M3 - Review article
C2 - 27832506
AN - SCOPUS:84994875729
SN - 0959-3993
VL - 33
JO - World Journal of Microbiology and Biotechnology
JF - World Journal of Microbiology and Biotechnology
IS - 1
M1 - 2
ER -
