TY - JOUR
T1 - Production of anti‐H‐2 antibodies in thymectomized mice
AU - Klein, J.
AU - Livnat, S.
AU - Hauptfeld, V.
AU - Jeřábek, L.
AU - Weissman, I.
PY - 1974/1
Y1 - 1974/1
N2 - Neonatally and adult thymectomized (Tx) mice of strains C57BL/10Sn and A. BY (H‐2b) were immunized at the age of 5 – 8 weeks with lethally irradiated spleen and lymph node cells from adult B 10. A and A (H‐2a) donors, respectively. The titer of H‐2 hemagglutinins and cytotoxins was determined at different intervals after immunization. Both untreated antibodies and antibodies reduced with 2‐mercaptoethanol (2‐Me) were tested. The non‐Tx control mice responded with production of both 2‐Me‐sensitive and 2‐Me‐resistant H‐2 antibodies. In the Tx mice, only 2‐Me‐sensitive H‐2 antibodies were detected. Thus, the anti‐H‐2 IgM response appears to be thymus‐independent and the anti‐H‐2 IgG response thymus‐dependent.
AB - Neonatally and adult thymectomized (Tx) mice of strains C57BL/10Sn and A. BY (H‐2b) were immunized at the age of 5 – 8 weeks with lethally irradiated spleen and lymph node cells from adult B 10. A and A (H‐2a) donors, respectively. The titer of H‐2 hemagglutinins and cytotoxins was determined at different intervals after immunization. Both untreated antibodies and antibodies reduced with 2‐mercaptoethanol (2‐Me) were tested. The non‐Tx control mice responded with production of both 2‐Me‐sensitive and 2‐Me‐resistant H‐2 antibodies. In the Tx mice, only 2‐Me‐sensitive H‐2 antibodies were detected. Thus, the anti‐H‐2 IgM response appears to be thymus‐independent and the anti‐H‐2 IgG response thymus‐dependent.
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U2 - 10.1002/eji.1830040111
DO - 10.1002/eji.1830040111
M3 - Article
C2 - 4853884
AN - SCOPUS:0015980522
SN - 0014-2980
VL - 4
SP - 41
EP - 44
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 1
ER -