Production of solavetivone by immobilized cells of Hyoscyamus muticus

S. V. Ramakrishna, G. Ramakrishna Reddy, Wayne R. Curtis, Arthur E. Humphrey

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The secretion of solavetivone, a phytoalexin, by the cells of Hyoscyamus muticus in response to fungal elicitation has been enhanced by gel entrapment in calcium alginate. The immobilized cells produced 53% higher product and exhibited sustained biosynthetic activity in repeated batch cycles when compared with suspended cells. Providing a non-elicited media exchange and a sufficient interval of time between repeated infection (elicitation) gave greater productivity. Apparently the cells need a period to recover from the infection.

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalBiotechnology Letters
Issue number3
StatePublished - Mar 1 1993

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


Dive into the research topics of 'Production of solavetivone by immobilized cells of Hyoscyamus muticus'. Together they form a unique fingerprint.

Cite this