TY - JOUR
T1 - Prognostic Role of Ammonia in Critical Care Patients Without Known Hepatic Disease
AU - Zhao, Lina
AU - Walline, Joseph Harold
AU - Gao, Yanxia
AU - Lu, Xin
AU - Yu, Shiyuan
AU - Ge, Zengzheng
AU - Zhu, Huadong
AU - Li, Yi
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China [grant numbers 81550034 and 81701893], the medical education grant from the Chinese Medical Science Academy (2018zlgc0101), State Administration of Foreign Experts Affairs P.R. China [grant number Q06090], and Dongcheng District Excellent Talents Development Project [grant number 11]. This work was supported by CAMS teaching reform research fund (grant number 2018zlgc0101). This work was supported by CAMS online open curse construction fund (grant number J2009022861).
Funding Information:
Funding. This work was supported by the National Natural Science Foundation of China [grant numbers 81550034 and 81701893], the medical education grant from the Chinese Medical Science Academy (2018zlgc0101), State Administration of Foreign Experts Affairs P.R. China [grant number Q06090], and Dongcheng District Excellent Talents Development Project [grant number 11]. This work was supported by CAMS teaching reform research fund (grant number 2018zlgc0101). This work was supported by CAMS online open curse construction fund (grant number J2009022861).
Publisher Copyright:
© Copyright © 2020 Zhao, Walline, Gao, Lu, Yu, Ge, Zhu and Li.
PY - 2020/10/22
Y1 - 2020/10/22
N2 - Background and Aims: Hyperammonemia usually develops because of hepatic disease, but it may occur in patients with non-hepatic hyperammonemia (NHH). But, studies on the prognosis and possible risk factors of this disorder are lacking. The aim of this study was to find possible prognostic and risk factors for NHH in critically ill patients. Methods: Data were extracted from MIMIC III Database. Survival was analyzed by the Kaplan-Meier method. Univariate and multivariate analyses were performed to identify prognostic factors. Results: Valproic acid, carbamazepine, corticosteroids, recent orthopedic surgery, epilepsy, disorders of urea cycle metabolism, and obesity were found to be risk factors for NHH. Patients in the hyperammonemia group had a higher 30 day mortality than those in the non-hyperammonemia group. After final regression analysis, ammonia was found to be independent predictors of mortality. Conclusion: Ammonia was an independent prognostic predictor of 30 day mortality for critical care patients without liver disease.
AB - Background and Aims: Hyperammonemia usually develops because of hepatic disease, but it may occur in patients with non-hepatic hyperammonemia (NHH). But, studies on the prognosis and possible risk factors of this disorder are lacking. The aim of this study was to find possible prognostic and risk factors for NHH in critically ill patients. Methods: Data were extracted from MIMIC III Database. Survival was analyzed by the Kaplan-Meier method. Univariate and multivariate analyses were performed to identify prognostic factors. Results: Valproic acid, carbamazepine, corticosteroids, recent orthopedic surgery, epilepsy, disorders of urea cycle metabolism, and obesity were found to be risk factors for NHH. Patients in the hyperammonemia group had a higher 30 day mortality than those in the non-hyperammonemia group. After final regression analysis, ammonia was found to be independent predictors of mortality. Conclusion: Ammonia was an independent prognostic predictor of 30 day mortality for critical care patients without liver disease.
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U2 - 10.3389/fmed.2020.589825
DO - 10.3389/fmed.2020.589825
M3 - Article
AN - SCOPUS:85095709189
SN - 2296-858X
VL - 7
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 589825
ER -