Prognostic significance of alterations in telomeric repeat length in patients with pathological stage I-II non-small cell lung cancer

T. Hirashima, T. Komiya, T. Nitta, M. Kobayashi, I. Kawase

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4 Scopus citations

Abstract

The purpose of this study was to evaluate the correlation between alteration in telomere length and prognosis in patients with pathological stage I-II non-small cell lung cancer. We measured telomeric repeat length and telomerase activity by use of southern blot analysis of terminal restriction fragments and a non-radioactive ELISA-based assay, respectively. RESULTS: Alterations in TRF lengths were present in 17(29.8%) of 57 patients. Patients with altered TRF length had significantly shorter survival than did patients without (P = 0.0051). In multivariate analysis, only alteration in TRF length independently correlated with shortened survival (P = 0.0033).

Original languageEnglish (US)
Pages (from-to)1264-1271
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Volume56
Issue number5
StatePublished - May 1998

All Science Journal Classification (ASJC) codes

  • General Medicine

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